Frequency, Trend, Predictors, and Impact of Gastrointestinal Bleeding in Atrial Fibrillation Hospitalizations
| Autor: | Mihir Dave, Monil Majmundar, Devina Adalja, Rupak Desai, Saraschandra Vallabhajosyula, Krunalkumar Patel, Nageshwara Gullapalli, Mariam Shariff, Gowthami Sai Kogilathota Jagirdhar, Rajkumar Doshi, Ashish Kumar, Palak Shah |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Gastrointestinal bleeding medicine.medical_specialty Adolescent Anemia 030204 cardiovascular system & hematology Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Atrial Fibrillation medicine Humans Hospital Mortality 030212 general & internal medicine Stroke Aged Retrospective Studies Aged 80 and over business.industry Anticoagulants Retrospective cohort study Atrial fibrillation Odds ratio Middle Aged medicine.disease United States Hospitalization Survival Rate Heart failure Cardiology Female Gastrointestinal Hemorrhage Cardiology and Cardiovascular Medicine business Follow-Up Studies Kidney disease |
| Zdroj: | The American Journal of Cardiology. 146:29-35 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/j.amjcard.2021.01.020 |
| Popis: | Anticoagulation alone or in combination with other treatment strategies are implemented to reduce the risk of stroke in patients with atrial fibrillation (AF). Gastrointestinal bleeding (GIB) is a common complication of oral anticoagulation with a prevalence of 1% to 3% in patients on long term oral anticoagulation. We analyzed the national inpatient sample database from the year 2005 to 2015 to report evidence on the frequency, trends, predictors, clinical outcomes, and economic burden of GIB among AF hospitalizations. A total of 34,260,000 AF hospitalizations without GIB and 1,846,259 hospitalizations with GIB (5.39%) were included. The trend of AF hospitalizations with GIB per 100 AF hospitalizations remained stable from the year 2005 to 2015 (p value = 0.0562). AF hospitalizations with GIB had a higher frequency of congestive heart failure, long term kidney disease, long term liver disease, anemia, and alcohol abuse compared with AF hospitalizations without GIB. AF hospitalizations with GIB had a higher odds of in-hospital mortality (Odds ratio (OR) 1.47; 95% Confidence interval (CI): 1.46 to 1.48, p-value0.0001), mechanical ventilation (OR 1.69; 95% CI: 1.68 to 1.70, p-value0.0001), and blood transfusion (OR 7.2; 95% CI: 7.17 to 7.22, P-value0.0001) compared with AF hospitalizations without GIB. AF hospitalizations with GIB had a lower odds of stroke (OR 0.51; 95% CI: 0.51 to 0.52, p-value0.0001) compared with AF hospitalizations without GIB. Further, AF hospitalizations with GIB had a higher median length of stay and cost of hospitalization compared with AF hospitalizations without GIB. In conclusion, the frequency of GIB is 5.4% in AF hospitalizations and the frequency of GIB remained stable in the last decade as shown in this analysis. When GIB occurs, it is associated with higher resource utilization. This study addresses a significant knowledge gap highlighting national temporal trends of GIB and associated outcomes in AF hospitalizations. |
| Databáze: | OpenAIRE |
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