Polymorphisms of two loci at the oxytocin receptor gene in populations of Africa, Asia and South Europe
| Autor: | E. M. Sukhodolskaya, Vasily A. Vasiliev, Elena N. Peletskaya, Marina Butovskaya, P. R. Butovskaya, Juliya N. Fedenok, Daria Dronova, Oleg E. Lazebny, Aracelli Rosa, Alexey P. Ryskov |
|---|---|
| Přispěvatelé: | Universitat de Barcelona |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Human behavior Culture Hormone receptors Ob Urgic Loss of heterozygosity 0302 clinical medicine Gene Frequency Genetics(clinical) Genetics (clinical) Genetics Sex Characteristics education.field_of_study rs2254298 Middle Aged Europe Phylogeography Fixation (population genetics) Receptors Oxytocin Female Catalans Research Article Adult Asia Adolescent Population SNP Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Young Adult 03 medical and health sciences Datoga Oxytocin receptor gene Humans 1000 Genomes Project Allele education Allele frequency Aged Receptors d'hormones Racial Groups Conducta (Psicologia) Proteins Oxytocin receptor 030104 developmental biology rs53576 Africa Hadza Proteïnes 030217 neurology & neurosurgery Parental behavior |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname BMC Genetics |
| Popis: | Background The oxytocin (OT) system is known to be implicated in the regulation of complex social behavior, particularly empathy and parenting. The goal of this study was to estimate the gender and population differences in polymorphisms of two oxytocin receptor gene SNPs, rs53576 and rs2254298, in four populations. Results These data were compared with each other and with 14 samples from the corresponding regions retrieved from the 1000 Genomes database. Low level of heterozygosity was observed for both SNPs in all populations in this study (rs53576: Catalonian, Hobs = 0.413; Hadza, Hobs = 0.556; sr2254698: Khanty-Mansi, Hobs = 0.250; Datoga, Hobs = 0.550). The amount of variance due to regional variability was almost equal for both SNPs (rs53576: FRT = 0.086, rs2554298: FRT = 0.072), whereas variance for the population level of variability was twice bigger for rs2554298 (rs53576: FST = 0.127, rs2554298: FST = 0.162). Pairwise coefficients of fixation demonstrate that the Hadza were well differentiated from other African populations except of Datoga, the Datoga were weakly differentiated from other African origin populations, the Ob Ugric people were extremely differentiated from all other populations. Catalans were extremely differentiated of Asian populations. Conclusions It is hypothesized on the base of spatial distribution of the evolutionary novel A alleles of the both OXTR gene loci, that the spread of alleles of rs22542298 and rs53376 SNPs may be associated to some extant with manipulation of parental investment in humans. Electronic supplementary material The online version of this article (doi:10.1186/s12863-015-0323-8) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|