Multiple epitopes of the human ovarian cancer antigen 14C1 recognised by human IgG antibodies: their potential in immunotherapy
| Autor: | G. Gallagher, F. al-Azzawi, G. Wilson, J. Handley, L. P. Walsh |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Cytotoxicity Immunologic DNA Replication Cancer Research medicine.drug_class medicine.medical_treatment Blotting Western Enzyme-Linked Immunosorbent Assay Antigen-Antibody Complex Biology Monoclonal antibody Epitope Immunoglobulin G Cell Line Epitopes Antigen Antigens Neoplasm medicine Humans Lymphocytes Cells Cultured Ovarian Neoplasms Immunotherapy medicine.disease Oncology Macrophage-1 antigen Immunology biology.protein Female Antibody Ovarian cancer Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1991.235 |
| Popis: | We have defined a novel ovarian cancer-associated membrane antigen, 14C1, using human monoclonal antibodies derived by EBV-transformation of in situ sensitised patients' B-cells. The pattern of recognition of this antigen by these antibodies suggests that at least three epitopes are discernable. These antibodies can be used to promote the in vitro killing of ovarian cancer cells by activated macrophages and cytokines, implying a role for this antigen in the immunotherapy of ovarian malignancies. Evidence is presented that the 14C1 antigen may have some transmembrane signalling function. Images Figure 1 |
| Databáze: | OpenAIRE |
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