Re-examining crude coal tar treatment for psoriasis
| Autor: | R.M. Mackie, D.M. Tillman, S.I. White, R.E.A. Williams, E. L. Barnett |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Administration Topical Dermatology complex mixtures Drug Administration Schedule Animal science Double-Blind Method Psoriasis otorhinolaryngologic diseases medicine Humans Coal tar Coal Tar Aged Dose-Response Relationship Drug business.industry Middle Aged medicine.disease Surgery Regimen Female Yellow soft paraffin business medicine.drug |
| Zdroj: | British Journal of Dermatology. 126:608-610 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/j.1365-2133.1992.tb00108.x |
| Popis: | Summary Two separate. double-blind, randomized, half-and-half body comparisons, each involving 20 inpatients with psoriasis, were conducted to compare the effect of different concentrations of crude coal tar in yellow soft paraffin. The therapeutic effect of 1% crude coal tar used twice daily for 10 days was significantly less than that achieved with an incremental regimen starting at 5% and increasing by 5% every second day to a maximum of 25%. No such difference was seen when a steady concentration of 5% was compared with the same incremental regimen. We conclude that there appears to be no benefit from exceeding a concentration of 5% crude coal tar in yellow soft paraffin in the treatment of patients with psoriasis and that the plateau in the dose-response curve for the action of crude coal tar in psoriasis begins at a point between 1 and 5%. |
| Databáze: | OpenAIRE |
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