The prognostic value of early onset, CT derived loss of muscle and adipose tissue during chemotherapy in metastatic non-small cell lung cancer

Autor: Karin J. C. Sanders, E.E.C. De Jong, Egbert F. Smit, Juliette H R J Degens, Anne-Marie C. Dingemans, Joachim G.J.V. Aerts, Annemie M. W. J. Schols, Harry J.M. Groen
Přispěvatelé: Pulmonary Medicine, RS: NUTRIM - R3 - Respiratory & Age-related Health, Pulmonologie, Promovendi NTM, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Promovendi ODB, Radiotherapie, MUMC+: MA Med Staf Spec Longziekten (9)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Body composition changes
Cancer Research
Lung Neoplasms
medicine.medical_treatment
PACLITAXEL-CARBOPLATIN-BEVACIZUMAB
Adipose tissue
Gastroenterology
0302 clinical medicine
Non-small cell lung cancer
Carcinoma
Non-Small-Cell Lung
Antineoplastic Combined Chemotherapy Protocols
CACHEXIA
Overall survival
Neoplasm Metastasis
Wasting
Stage IV
Middle Aged
Prognosis
medicine.anatomical_structure
Adipose Tissue
Oncology
030220 oncology & carcinogenesis
OBESITY
Metastatic
Female
CLINICAL-IMPLICATIONS
medicine.symptom
DEPLETION
Adult
Pulmonary and Respiratory Medicine
medicine.medical_specialty
MASS
SARCOPENIA
Cachexia
03 medical and health sciences
Lumbar
SDG 3 - Good Health and Well-being
Predictive Value of Tests
Internal medicine
medicine
Humans
COMPUTED-TOMOGRAPHY
Muscle
Skeletal
Lung cancer
Aged
Neoplasm Staging
Chemotherapy
business.industry
Skeletal muscle
medicine.disease
Survival Analysis
030104 developmental biology
Sarcopenia
Atrophy
Tomography
X-Ray Computed
business
Zdroj: Lung Cancer, 133, 130-135. ELSEVIER IRELAND LTD
Lung Cancer, 133, 130-135. Elsevier Ireland Ltd
ISSN: 0169-5002
Popis: Objectives: To evaluate the relationship between early changes in muscle and adipose tissue during chemotherapy and overall survival (OS) in stage IV non-small cell lung cancer (NSCLC).Materials and methods: In this post-hoc analysis of the first line NVALT12 trial (NCT01171170) in stage IV NSCLC, skeletal muscle (SM), radiation attenuation (RA), subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) were assessed at the third lumbar level on CT-images obtained before initiation of chemotherapy and shortly after administration of the second cycle. The contribution of changes in different body compartments to overall survival was assessed.Results: CT scans of 111 patients were included. Analysis of body composition changes between the baseline and the follow-up scan, revealed that overall SM cross sectional area (CSA), radiation attenuation and SAT CSA decreased respectively by -1.2 +/- 2.9 cm(2)/m(2) (p Conclusion: Early loss of SM during first line chemotherapy is a poor prognostic factor in stage IV NSCLC patients. Future studies have to reveal whether early supportive intervention guided by initial CT muscle response to chemotherapy can influence the wasting process and related mortality risk.
Databáze: OpenAIRE
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