Increased risk of preneoplastic colonic lesions and colorectal carcinoma in acromegaly: multicenter case-control study
| Autor: | Susana Mallea-Gil, Marisa Servidio, María Florencia Battistone, Karina Danilowicz, Maria Carolina Ballarino, Marcela Martinez, Ignacio Federico Caldo, Marina Donoso, Natalia García-Basavilbaso, Patricia Slavinsky, Laura Boero, Graciela Stalldecker, Amelia Rogozinski, Grabriela Szuman, Mariela Glerean, Soledad Sosa, Maria Isabel Sabaté, Karina Miragaya, Daniela Lubieniecki, Monica Graciela Loto, Mirtha Guitelman, Débora Katz, Julieta Tkatch, Monica Agüero, Alejandra Furioso, Analía Alfieri, Sabrina Diez, Patricia Fainstein-Day |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Colorectal cancer Endocrinology Diabetes and Metabolism Colonoscopy 030209 endocrinology & metabolism Gastroenterology 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Polyps Internal medicine Acromegaly Medicine Humans Multicenter Studies as Topic Aged Retrospective Studies medicine.diagnostic_test business.industry Case-control study Retrospective cohort study Middle Aged medicine.disease Precancerous Polyp Increased risk Case-Control Studies Female business 030217 neurology & neurosurgery |
| Zdroj: | Pituitary. 24(1) |
| ISSN: | 1573-7403 |
| Popis: | Current international guidelines recommend colonoscopy in patients with acromegaly at the time of diagnosis, even though the risk of developing colorectal neoplasm is still controversial. The main objective of this Argentine multicenter study was to analyze through screening colonoscopy the presence of advanced neoplastic lesions considered as precancerous, in patients with acromegaly compared to a control group. This is a case–control retrospective study. Full length colonoscopy of 70 acromegalic patients and 128 control subjects were studied. Polyps were classified into non pre-cancerous lesions and advance neoplastic lesions which included advanced adenomas (preneoplastic) and colorectal carcinomas. Thirty three out of 70 acromegalic patients and 32 out of 128 subjects controls presented polyps in the colonoscopy [47.1% vs 25%, p = 0.002, OR 2.68]. Non precancerous polyps were found in 11 (15.7%) and 23 (17.9%) (p = 0.690), while advanced neoplastic lesions were found in 22 (31.4%) and 9 (7.0%) (p = 0,0001 – OR: 6.06) patients and controls respectively. Advanced adenomas and colorectal carcinomas were found in 18 (27.3%) and 9 (7.0%) (p = 0,0006—OR: 4,57), and 4 (5.7%) and 0 (0.0%) p = 0.0063) of patients and controls respectively. The presence of insulin resistance was the only statistically significant associated factor among acromegalic patients with and without colonic polyps. Our findings show an increased risk of preneoplastic colonic lesions and colorectal carcinoma in patients with chronic and sustained GH excess compared to a control group. This supports the recommendation to perform screening colonoscopy at diagnosis of acromegaly. |
| Databáze: | OpenAIRE |
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