c-Ski in health and disease
| Autor: | Suzana Atanasoski, Carine Bonnon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Models
Molecular Histology animal structures Molecular Sequence Data Receptors Cytoplasmic and Nuclear Biology Proteomics Bioinformatics DNA-binding protein Pathology and Forensic Medicine 03 medical and health sciences Neoplasms Proto-Oncogene Proteins Animals Humans Amino Acid Sequence Receptor Transcription factor Phylogeny 030304 developmental biology 0303 health sciences 030302 biochemistry & molecular biology Cell Biology musculoskeletal system Human genetics Protein Structure Tertiary 3. Good health Cell biology DNA-Binding Proteins Nuclear receptor Tumor progression Disease Progression Signal transduction Sequence Alignment human activities Signal Transduction Transcription Factors |
| Zdroj: | Cell and tissue research |
| Popis: | c-Ski is an evolutionary conserved protein that is involved in diverse cellular processes such as proliferation, differentiation, transformation, and tumor progression. A large range of cellular partners of c-Ski, including transcription factors, chromatin-remodeling molecules, tumor suppressors, and nuclear hormone receptors, has been identified. Moreover, numerous mechanisms have been described by which c-Ski regulates essential signaling pathways, e.g., the TGFβ pathway. In this review, we summarize the diverse roles attributed to c-Ski during normal development and in cancer progression and discuss future strategies to unravel further the complex nature of c-Ski actions in a context-dependent manner. |
| Databáze: | OpenAIRE |
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