Synthesis and antiprotozoal activity of some new synthetic substituted quinoxalines

Autor:	Xavier Franck, Xu Hui, Bruno Figadère, Philippe M. Loiseau, Reynald Hocquemiller, Julie Desrivot, Christian Bories
Rok vydání:	2006
Předmět:	medicine.drug_class Stereochemistry Trypanosoma brucei brucei Clinical Biochemistry Antiprotozoal Agents Leishmania donovani Pharmaceutical Science Carboxamide macromolecular substances In Vitro Techniques Trypanosoma brucei medicine.disease_cause Biochemistry Chemical synthesis Structure-Activity Relationship chemistry.chemical_compound Antiprotozoal Agent Quinoxaline Parasitic Sensitivity Tests Quinoxalines parasitic diseases Drug Discovery Trichomonas vaginalis medicine Animals IC50 Molecular Biology Molecular Structure biology Organic Chemistry General Medicine biology.organism_classification In vitro chemistry Antiprotozoal Molecular Medicine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 16:815-820
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2005.11.025
Popis:	A series of 29 new quinoxalines was synthesized and evaluated in vitro against several parasites (Leishmania donovani, Trypanosoma brucei brucei, and Trichomonas vaginalis). Several of them displayed interesting activities, and particularly four quinoxaline amides showed in vitro antileishmanial properties (IC50 less than 20 microM).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0327ef491071447ed215ac40259aa4ef https://doi.org/10.1016/j.bmcl.2005.11.025 Zobrazit plný text záznamu Full Text from ScienceDirect