The use of antipsychotics in preschoolers: A veto or a sensible last option?
| Autor: | Jessica Memarzia, Derek K. Tracy, Giovanni Giaroli |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Psychotherapist Veto Alternative medicine Context (language use) Animals Humans Medicine Pharmacology (medical) Risks and benefits Practice Patterns Physicians' Adverse effect Psychiatry Pharmacology Relative efficacy business.industry Age Factors Treatment efficacy Clinical Practice Psychiatry and Mental health Psychotic Disorders Child Preschool Practice Guidelines as Topic business Antipsychotic Agents |
| Zdroj: | Journal of Psychopharmacology. 28:303-319 |
| ISSN: | 1461-7285 0269-8811 |
| DOI: | 10.1177/0269881113519506 |
| Popis: | Recent reports have illustrated a dramatic rise in the use of antipsychotics in preschool children, medications originally designed and licensed for the treatment of adult psychotic disorders. Within this context, the current usage and the associated diagnoses are reviewed and compared with official guidelines and licensing for such use, highlighting a controversial challenge for clinicians. A review of the evidence base of the relative efficacy of such medications for a range of disorders is given. Associated safety and side effects are discussed, with compelling evidence for increased adverse events associated with use of antipsychotics in preschoolers, and neurodevelopmental hypotheses are used to guide predictions of long-term risk. An apparent gap in the literature and evidence base supporting such use and elucidating the risks and benefits leaves a challenge for clinicians and researchers and hinders the development of appropriate guidelines. Pragmatism in clinical practice, mindful of the limited evidence base that does exist and the propensity for harm, is necessary; far more research is required in this important area. |
| Databáze: | OpenAIRE |
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