Effects of cidofovir treatment on cytokine induction in murine models of cowpox and vaccinia virus infection
| Autor: | Donald F. Smee, Corinna W. Knorr, Anthony R. Torres, S. D. Allen |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
viruses
Cowpox Organophosphonates Vaccinia virus Biology Antiviral Agents Virus Cytosine Mice chemistry.chemical_compound Interferon Virology Vaccinia medicine Animals Poxviridae Orthopoxvirus Lung Pharmacology Mice Inbred BALB C Cowpox virus medicine.disease biology.organism_classification Disease Models Animal chemistry Immunology Cytokines Female Cidofovir medicine.drug |
| Zdroj: | Antiviral Research. 72:125-133 |
| ISSN: | 0166-3542 |
| Popis: | Cytokine profiles during cowpox and vaccinia (WR strain) virus infections were characterized in intranasal (i.n.) and intraperitoneal (i.p.) models in BALB/c mice. The time-course of induction and effects of cidofovir treatment on interferon (IFN)-gamma, IFN-gamma inducible protein (IP)-10, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1 were determined. The four mouse infection models have distinct patterns of cytokine induction. Cowpox virus i.p. and vaccinia virus i.n. infections showed increased induction throughout the time studied. Cowpox virus i.n. infection resulted in delayed induction of IFN-gamma and IP-10. Cytokine levels were fairly constant during vaccinia virus i.p. infections. Cidofovir treatment (100mg/kg/day i.p. for 2 days) significantly suppressed certain cytokine (IFN- gamma, IL-6, IL-10, IL-11, IP-10, LIF, MCP-1, MCP-3, MCP-5, MIP-1 gamma, and TIMP-1) levels to near normal relative to uninfected animals, as well as prevented mortality and reduced virus titers significantly. Characterization of cytokine responses has implications for understanding the immune responses and pathogeneses of viral infections in these mouse models. |
| Databáze: | OpenAIRE |
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