Patient survival following joint replacement due to metastatic bone disease – comparison of overall patient and prostheses survival between cohorts treated in two different time-periods
| Autor: | Thea Bechmann Hovgaard, Michala Skovlund Sørensen, Michael Mørk Petersen, Peter Frederik Horstmann |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Reoperation medicine.medical_specialty Time Factors Bone disease Joint replacement Joint Prosthesis medicine.medical_treatment Bone Neoplasms Kaplan-Meier Estimate Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Epidemiology medicine Humans Radiology Nuclear Medicine and imaging Cumulative incidence Arthroplasty Replacement Aged Retrospective Studies Aged 80 and over 030222 orthopedics business.industry Cancer Implant failure Hematology General Medicine Middle Aged medicine.disease Prosthesis Failure Surgery Oncology 030220 oncology & carcinogenesis Cohort Female Implant business |
| Zdroj: | Acta Oncologica. 57:839-848 |
| ISSN: | 1651-226X 0284-186X |
| DOI: | 10.1080/0284186x.2017.1420910 |
| Popis: | BACKGROUND Improvements in medical treatment for cancer have increased survival of cancer patients. We hypothesize that improvement in cancer treatment is reflected in increased survival after surgical intervention for metastatic bone disease (MBD) and that subsequent revision surgery does not pose a risk for survival. METHODS We identified a retrospective consecutive cohort who received bone resection and reconstruction (BRR) with implants (including total joint replacements (with or without wide resection) or bone reconstruction with an intercalary spacer or revisions procedures for failed implants with BBR technique) due to MBD from 2003 to 2008 (early cohort) and 2009 to 2013 (late cohort) at a tertiary referral center. We registered epidemiological data, type of implant (primary or a revision implant), patient survival (Kaplan-Meier), implant survival (competing risk analysis) and complications to surgery. RESULTS Three hundred and eleven procedures were performed in 291 patients (289 primary BRR (270 patients, early cohort n = 130 late cohort n = 140) and 22 revision BRR (21 patients)). Overall survival was 44% (95% confidence intervals (95% CI): 39-50) and 32% (95% CI: 27-38) after 1 and 2 years. No difference in survival between the early and late cohort was found (p = .458), or between primary and revision BRR (p = .465). Time from diagnosis of cancer to surgery was shorter in the early cohort (p |
| Databáze: | OpenAIRE |
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