Changes in the ganglion cell complex thickness after anti-VEGF treatment for diabetic macular edema
| Autor: | Fikret Unal, Nese Cetin Dogan, Emine Ciloglu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Vascular Endothelial Growth Factor A
Nervous system medicine.medical_specialty Visual acuity genetic structures Endothelium Cell complex Tomography optical coherence Visual Acuity Angiogenesis Inhibitors Diabetes mellitus Optical coherence tomography Edema Ophthalmology Ganglion cell complex medicine Humans Anti-vascular endothelial growth factor Macular edema Diabetic Retinopathy medicine.diagnostic_test business.industry Neurodegenerative diseases General Medicine Middle Aged RE1-994 medicine.disease eye diseases Ganglion Bevacizumab Treatment Outcome medicine.anatomical_structure Intravitreal Injections sense organs medicine.symptom business |
| Zdroj: | Arquivos Brasileiros de Oftalmologia, Vol 83, Iss 5, Pp 372-377 (2020) Arquivos Brasileiros de Oftalmologia v.83 n.5 2020 Arquivos brasileiros de oftalmologia Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
| ISSN: | 1678-2925 |
| Popis: | Purpose: To assess tomographic ganglion cell complex changes in patients with diabetic macular edema treated with intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF). Methods: We analyzed data from 35 eyes of 35 previously untreated patients in whom diabetic macular edema improved after three loading doses of anti-VEGF injection and who did not receive repeated injections. We recorded spectral domain-optical coherence tomography assessments of ganglion cell complex and central macular thickness at baseline and monthly for three months, and on the sixth and ninth month after treatment. We compared the results with those of the unaffected eyes in the same patients and with those in a control group of patients with diabetic macular edema who were untreated. Results: The mean age of the patients in the treatment group was 60 ± 4.38 years. The foveal thicknesses measured using optical coherence tomography decreased significantly from baseline to the third month post-injection (p0.05) and 113.12 ± 11.15 µm on the ninth month (p>0.05). We found a significant difference between the patients and the control group in terms of mean ganglion cell complex thickness on the second- and third-months post-injection (p |
| Databáze: | OpenAIRE |
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