The virulence of trimethoprim-resistant thymine-requiring strains ofSalmonella
| Autor: | H. W. Smith, J. F. Tucker |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Salmonella typhimurium
Salmonella food.ingredient Injections Subcutaneous Immunology Mutant Administration Oral Virulence Biology medicine.disease_cause Trimethoprim Microbiology Feces Mice chemistry.chemical_compound food medicine Animals Agar Public Health Environmental and Occupational Health Drug Resistance Microbial Virology In vitro Thymine chemistry Mutation Chickens Digestive System Research Article medicine.drug |
| Zdroj: | Journal of Hygiene. 76:97-108 |
| ISSN: | 0022-1724 |
| DOI: | 10.1017/s0022172400054991 |
| Popis: | SUMMARYA thymine-requiring (thy−), trimethoprim-resistant (tmpr) mutant isolated from the faeces of chickens experimentally infected withSalmonella typhimuriumand treated with a mixture of trimethoprim and sulphadiazine was less virulent for chickens than the parent strain and athy+tmpsrevertant preparedin vitrofrom the mutant. The difference in chicken-virulence was more noticeable when the strains were administered orally than when they were administered subcutaneously. Alltmprmutants preparedin vitrofrom four other salmonella strains were alsothy−; those tested were less virulent for chickens and mice than their parent strains. After oral infection,thy−salmonella organisms were found much less commonly in the alimentary tract of chickens then werethy+organisms. This was especially so in the caeca, the principal site of colonization of both thethy+andthy−organisms. Relatively high concentrations of thymine or related compounds were found in the contents of all regions of the alimentary tract of chickens except the caeca; the caeca usually contained low or undetectable concentrations.Thethy−salmonella strains would not grow on one brand of brilliant green agar because of its deficiency in thymine; their colonial appearance on other kinds of media used for isolating salmonellae from clinical material was often ‘un-salmonella-like’. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|