Different distribution of c-myc and MIB-1 positive cells in malignant meningiomas with reference to TGFs, PDGF, and PgR expression
| Autor: | Goro Nagashima, Jun-ichirou Asai, Ryuta Suzuki, Tsukasa Fujimoto |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty medicine.medical_treatment Proto-Oncogene Proteins c-myc Meningioma Progesterone receptor Meningeal Neoplasms otorhinolaryngologic diseases medicine Humans Tissue Distribution neoplasms Aged Platelet-Derived Growth Factor biology Growth factor Antibodies Monoclonal General Medicine Middle Aged medicine.disease Immunohistochemistry nervous system diseases Ki-67 Antigen Oncology Transforming Growth Factors Ki-67 Benign Meningioma biology.protein Female Neurology (clinical) Receptors Progesterone Immunostaining Platelet-derived growth factor receptor Transforming growth factor |
| Zdroj: | Brain Tumor Pathology. 18:1-5 |
| ISSN: | 1861-387X 1433-7398 |
| Popis: | We investigated the expression of transforming growth factors (TGFs), platelet-derived growth factor (PDGF), progesterone receptor (PgR), and c-myc in 20 cases of meningioma of various grades: 17 benign, 2 atypical, and 1 anaplastic. All cases of atypical and anaplastic meningioma were positive for c-myc, whereas all 17 benign meningiomas were negative for c-myc immunostaining. Expression of TGF-alpha, TGF-beta, and PDGF-BB proteins was seen in more than 80% of the meningioma cases and was not restricted to their histological grade of meningioma. PgR was expressed mainly in benign meningiomas. Moreover, the cells expressing c-myc protein were not usually stained by MIB-1. These results indicate that c-myc does not directly work on the proliferation of meningioma cells, and even in homogeneous meningioma cells, there may be many functional variations that lead the meningioma cells to their growth. |
| Databáze: | OpenAIRE |
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