Impact of Increased Hemoglobin on Spontaneous Intracerebral Hemorrhage

Autor: Wei Sun, Xiaoting Luan, Yuxian Li, Shouzi Zhang, Yuxuan Lu, Dunzhu Mima, Cidan Zhuoga, Luzeng Chen, Siwei Chen, Shunliang Xu, Feiqi Zhu, Yongan Sun, Yuhua Zhao, Jun Xu, Haiqiang Jin, Jiayu Tian
Rok vydání: 2021
Předmět:
Zdroj: Neurocritical Care. 36:395-403
ISSN: 1556-0961
1541-6933
Popis: Background Studies of the impact of increased hemoglobin on spontaneous intracerebral hemorrhage (ICH) are limited. The present study aimed to explore the effect of increased hemoglobin on ICH. Methods A retrospective single-center study using medical records from a database processed by univariate and multivariate analyses was performed in the People’s Hospital of Tibet Autonomous Region in Lhasa, Tibet, China. Results The mean hemoglobin level in 211 patients with ICH was 165.03 ± 34.12 g/l, and a median hematoma volume was 18.5 ml. Eighty-eight (41.7%) patients had large hematomas (supratentorial hematoma ≥ 30 ml; infratentorial hematoma ≥ 10 ml). No differences in ICH risk factors between the groups with different hemoglobin levels were detected. Increased hemoglobin was independently associated with large hematomas [odds ratio (OR) 1.013, P = 0.023]. Increased hemoglobin was independently associated with ICH with subarachnoid hemorrhage (OR 1.014, P = 0.016), which was more pronounced in men (OR 1.027, P = 0.002). Increased hemoglobin was independently associated with basal ganglia hemorrhage and lobar hemorrhage in men (OR 0.986, P = 0.022; OR 1.013, P = 0.044, respectively) but not in women (P > 0.1). Conclusions Increased hemoglobin was independently associated with large hemorrhage volume. Increased hemoglobin was independently associated with lobar hemorrhage in men and ICH with subarachnoid hemorrhage, which was more pronounced in men. Additional studies are needed to confirm our findings and explore potential mechanisms.
Databáze: OpenAIRE
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