Effects of intracoelomic alfaxalone–dexmedetomidine on righting reflex in common garter snakes (Thamnophis sirtalis): preliminary data
| Autor: | Stuart C. Clark-Price, Kelly Chen, Danielle Strahl-Heldreth, Stephanie C. J. Keating |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
040301 veterinary sciences
Pilot Projects Pregnanediones Every 5 minutes 0403 veterinary science Immobilization Reflex Righting 03 medical and health sciences 0302 clinical medicine Heart Rate 030202 anesthesiology Heart rate medicine Animals Drug Interactions Dexmedetomidine Loss of righting reflex General Veterinary biology business.industry Alfaxalone Colubridae 04 agricultural and veterinary sciences biology.organism_classification Crossover study Anesthetics Combined Anesthesia Righting reflex Thamnophis sirtalis business medicine.drug |
| Zdroj: | Veterinary Anaesthesia and Analgesia. 47:793-796 |
| ISSN: | 1467-2987 |
| Popis: | Objective To evaluate the effect of dexmedetomidine on alfaxalone immobilization in snakes. Study design Nonblinded, crossover study. Animals A total of eight mature common garter snakes (Thamnophis sirtalis). Methods Snakes were administered each of three treatments intracoelomically: alfaxalone (30 mg kg–1; treatment A), alfaxalone (30 mg kg–1) combined with dexmedetomidine (0.05 mg kg–1; treatment AD0.05); and alfaxalone (30 mg kg–1) combined with dexmedetomidine (0.10 mg kg–1; treatment AD0.10). A minimum of 10 days elapsed between experimental trials. Times to loss of righting reflex (LRR) and return of righting reflex (RRR) were recorded. Heart rate (HR) was recorded every 5 minutes throughout the period of LRR and averaged for each snake. Times to LRR and RRR, and mean HR in snakes that achieved LRR were reported. Results LRR occurred in eight (100%), five (63%) and three (38%) snakes in treatments A, AD0.05 and AD0.10, respectively. For all treatments, time to LRR ranged 3–20 minutes. Median (range) times to RRR were 39 (30–46), 89 (62–128) and 77 (30–185) minutes for treatments A, AD0.05 and AD0.10, respectively. In animals where righting reflex was lost, mean HR was lower in all dexmedetomidine treatments compared with treatment A. Conclusions and clinical relevance In this pilot study, alfaxalone resulted in reliable immobilization, whereas dexmedetomidine and alfaxalone combinations resulted in highly variable durations of immobilization with low HR in immobilized animals. For snakes that achieved LRR, the addition of dexmedetomidine (0.05 mg kg–1) to alfaxalone appeared to extend the period of immobilization compared with alfaxalone alone. |
| Databáze: | OpenAIRE |
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