Bone regeneration and docking site healing after bone transport distraction osteogenesis in the canine mandible
Autor: | Uriel Zapata, Ibrahim Zakhary, Michelle Rondon-Newby, Lucy K. Nagashima, Lynne A. Opperman, William W. Nagy, Paul C. Dechow, Mohammed E. Elsalanty |
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Rok vydání: | 2010 |
Předmět: |
Bone Regeneration
Bone density medicine.medical_treatment Nonunion Bone Screws Osteogenesis Distraction Dentistry Bone healing Mandible Osteotomy Article Dogs Bone Density Hardness Osteogenesis Elastic Modulus Bone plate medicine Rosaniline Dyes Animals Bone regeneration Coloring Agents Ultrasonography Wound Healing business.industry Biomechanics Equipment Design medicine.disease Biomechanical Phenomena Otorhinolaryngology Models Animal Distraction osteogenesis Anisotropy Surgery Oral Surgery business Bone Plates |
Zdroj: | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 70(2) |
ISSN: | 1531-5053 |
Popis: | Purpose Bone transport distraction osteogenesis provides a promising alternative to traditional grafting techniques. However, existing bone transport distraction osteogenesis devices have many limitations. The purpose of this research was to test a new device, the mandibular bone transport reconstruction plate, in an animal model with comparable mandible size to humans and to histologically and mechanically examine the regenerate bone. Materials and Methods Eleven adult foxhounds were divided into an unreconstructed control group of 5 animals and an experimental group of 6 animals. In each animal, a 34-mm segmental defect was created in the mandible. The defect was reconstructed with a bone transport reconstruction plate. Histologic and biomechanical characteristics of the regenerate and unrepaired defect were analyzed and compared with bone on the contralateral side of the mandible after 4 weeks of consolidation. Results The reconstructed defect was bridged with new bone, with little bone in the control defect. Regenerate density and microhardness were 22.3% and 42.6%, respectively, lower than the contralateral normal bone. Likewise, the anisotropy of the experimental group was statistically lower than in the contralateral bone. Half the experimental animals showed nonunion at the docking site. Conclusion The device was very stable and easy to install and activate. After 1 month of consolidation, the defect was bridged with new bone, with evidence of active bone formation. Regenerate bone was less mature than the control bone. Studies are underway to identify when the regenerate properties compare with normal bone and to identify methods to augment bone union at the docking site. |
Databáze: | OpenAIRE |
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