BODIPY-Mn nanoassemblies for accurate MRI and phototherapy of hypoxic cancer
| Autor: | Jing Gao, Tao Huang, Qin-Mei Xu, Ke-Jing Xiao, Ya-Quan Lan, Yao Zhao, Qiu-Yun Chen, Wen-Long Lu, Ling-Ling Qu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_treatment
Biomedical Engineering Nanotechnology Photodynamic therapy 02 engineering and technology 010402 general chemistry 01 natural sciences Metastasis chemistry.chemical_compound In vivo medicine General Materials Science Bovine serum albumin Tumor hypoxia medicine.diagnostic_test biology business.industry Cancer Magnetic resonance imaging General Chemistry General Medicine 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences chemistry biology.protein Biophysics BODIPY 0210 nano-technology business |
| Zdroj: | Journal of materials chemistry. B. 5(6) |
| ISSN: | 2050-7518 |
| Popis: | Hypoxia promotes not only the metastasis of tumors but also therapeutic resistance. Photosensitizer-mediated consumption of O2 during photodynamic therapy (PDT) reinforces tumor hypoxia. Herein, a light-dependent attenuator of a hypoxic environment is reported for accurate MRI and phototherapy of hypoxic cancer. First, a photoresponsive Mn(II) nanoassembly was constructed, then it was assembled with bovine serum albumin (BSA) and modified with polyethylene glycol–folic acid (PEG–FA), forming cancer targeting Mn–DBA@BSA–FA nanoassemblies, which offer T1 signals and can catalyze the water oxidation reaction under irradiation of red light emitting diode (LED) light with the generation of O2 and heat. Moreover, they could selectively penetrate through and accumulate in the tumor tissues with clear T1 magnetic resonance imaging (MRI) signals, and have remarkably eliminated the tumors in vivo, while they are of low toxicity to the healthy organs. The release of the Mn(II) complex from the nanoparticles in an acidic environment and the in vivo biodistribution results confirm the selective cancer targeting. Our work demonstrates the potential of nanoparticles as excellent theranostic agents for MR imaging combined with phototherapy triggered by near-infrared light. |
| Databáze: | OpenAIRE |
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