Low-frequency electroacupncture improves locomotor function after sciatic crushed nerve injury in rats
| Autor: | Jinhee Seo, Lakkyong Hwang, Sang-Hoon Kim, Key-Moon Shin, Yong Gil Na, Bo-Kyun Kim, Jun-Jang Jin, Sung Eun Kim, Il-Gyu Ko |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Electroacupuncture medicine.medical_treatment Physical Therapy Sports Therapy and Rehabilitation Stimulation Neurofilament c-Fos Periaqueductal gray Brain-derived neurotrophic factor 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Acupuncture Orthopedics and Sports Medicine biology business.industry medicine.disease 030104 developmental biology Endocrinology nervous system Crush injury biology.protein Original Article Sciatic nerve business 030217 neurology & neurosurgery Scientific functional index |
| Zdroj: | Journal of Exercise Rehabilitation |
| ISSN: | 2288-176X |
| Popis: | Sciatic crushed nerve injury (SCI) causes pain-related gait and swelling in the affected limb. Electroacupuncture (EA) is a modified acupuncture technique, and analgesic effect of EA on different types of pain has been documented. Scientific functional index (SFI) is a mathematical formula to represent parameters of normal and experimental footprints. We investigated the effect of low-frequency EA on functional recovery following SCI in rats. For this study, immunohistochemistry for c-Fos in the ventral lateral periaqueductal gray (vlPAG) and paraventricular nucleus (PVN) and western blot for neurofilament (NF) and brain-derived neurotrophic factor (BDNF) in the sciatic nerve were conducted. To induce crush injury on the sciatic nerve, sciatic nerve was crushed for 30 sec using a surgical clip. The rats in the acupuncture groups received acupuncture bilaterally at respective site, once a day for 14 days. The rats in the EA group received 100-Hz electrical stimulation for 10 min once a day during 14 days. SCI decreased SFI value, in contrast, EA increased SFI value. c-Fos expression in the vlPAG and PVN was increased following SCI, in contrast, EA suppressed c-Fos expression. NF expression in the sciatic nerve was decreased by SCI, in contrast, EA increased NF expression. BDNF expression in the sciatic nerve was increased by SCI, in contrast, EA suppressed BDNF expression. In the present study, EA showed effectiveness on functional recovery from SCI. |
| Databáze: | OpenAIRE |
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