Understanding the dipyrone oxidation allying electrochemical and computational approaches
| Autor: | Camila P. Sousa, Janete Eliza de Sá Soares, Rayane N. Gomes, Pedro de Lima-Neto, Adriana N. Correia, Samuel Lucas Santos Medeiros, Helena Becker, João R. Bezerra-Neto |
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| Rok vydání: | 2019 |
| Předmět: |
Models
Molecular Dipyrone Molecular Conformation Analytical chemistry 02 engineering and technology Electrochemistry 01 natural sciences Biochemistry Analytical Chemistry Iodometry Limit of Detection Humans Environmental Chemistry Routine analysis Voltammetry Density Functional Theory Spectroscopy Detection limit Chemistry Natural water 010401 analytical chemistry Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology 0104 chemical sciences Electrode Cyclic voltammetry 0210 nano-technology Oxidation-Reduction |
| Zdroj: | Analytica Chimica Acta. 1051:49-57 |
| ISSN: | 0003-2670 |
| Popis: | Electroanalytical methodology by boron-doped diamond electrode (BDDE) associated to the square-wave voltammetry (SWV) for the determination of hydrolyzed dipyrone (DIP) in commercial formulations, raw natural waters and in human urine was developed. Through cyclic voltammetry (CV), it was shown that the oxidation of the DIP on the BDDE was irreversible with diffusional control. Computational studies suggested that the oxidation mechanism of DIP occurred with participation of two electrons and one proton. The analytical curves were obtained for concentrations of DIP ranging from 1.0 × 10−6 to 6.5 × 10−5 mol L−1 (r = 0.9994). The values of detection limit (LOD) and quantification limit (LOQ) of DIP were calculated from SWV and found to be 2.6 × 10−7 mol L−1 and 8.8 × 10−7 mol L−1. The methodology was effectively applied to real samples with the values of calculated recoveries varying between 91.0% and 117.3% and validated by iodometric titration experiments whose values were between 93.3% and 106.9%. The proposed methodology with BDDE represents an alternative tool and it has advantageous, such as very easy handling, low cost, no need for modification, low detection limit. Furthermore, it can be used for the routine analysis of DIP in different real samples. |
| Databáze: | OpenAIRE |
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