Pre-operative Redox State Affects 1-Month Survival in Patients With Advanced Heart Failure Undergoing Left Ventricular Assist Device Implantation
| Autor: | Emanuele Catena, Maria Frigerio, Filippo Milazzo, Oberdan Parodi, Ettore Vitali, Andrea Garatti, Tiziano Colombo, Valentina Sedda, Jonica Campolo, Raffaele Caruso, Giuliana Cighetti, Claudio Russo |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Heart disease Heart Ventricles medicine.medical_treatment medicine.disease_cause law.invention Glutathione Peroxidase GPX1 Predictive Value of Tests law Malondialdehyde Artificial heart Internal medicine medicine Humans Survival analysis Aged Heart Failure Glutathione Peroxidase Transplantation business.industry Middle Aged equipment and supplies medicine.disease Glutathione Survival Analysis Surgery Oxidative Stress Glutathione Reductase Treatment Outcome Case-Control Studies Ventricular assist device Predictive value of tests Heart failure Cardiology Female Heart-Assist Devices Cardiology and Cardiovascular Medicine business Oxidation-Reduction Biomarkers Oxidative stress |
| Zdroj: | The Journal of Heart and Lung Transplantation. 26:1177-1181 |
| ISSN: | 1053-2498 |
| DOI: | 10.1016/j.healun.2007.07.009 |
| Popis: | Background Left ventricular assist device (LVAD) implantation has proven effective as a bridge to transplantation in end-stage heart failure patients (ESHFPs), although survival during device support is critical. Oxidative stress has been implicated in the development of heart failure, but the influence of redox state on in-hospital post-LVAD outcome has not been clarified. Methods and Results In this report we describe the oxidant/anti-oxidant profiles of 15 ESHFPs before LVAD placement, 5 of whom did not survive to 1 month, and in 30 subjects without cardiac disease, representing the control group. Conclusions Preliminary findings suggest that adequate activity of the GPx-1–based anti-oxidant system before device placement is associated with patient survival up to 1 month, despite comparable baseline oxidative stress in patients who both survived and died (within 2 weeks post-LVAD). |
| Databáze: | OpenAIRE |
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