Co-crystallization of zinc sulfate with sucrose: A promissory strategy to render zinc solid dosage forms more palatable
| Autor: | Alex López-Córdoba, Alba Sofia del Rosario Navarro, Loreana Gallo, Verónica Bucalá, Miriam Nora Martino |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Sucrose Water activity Otras Ingenierías y Tecnologías Mineralogy chemistry.chemical_element Zinc Chemical interaction TABLETS INGENIERÍAS Y TECNOLOGÍAS Dosage form law.invention CO-CRYSTALLIZATION Alimentos y Bebidas 03 medical and health sciences chemistry.chemical_compound ZINC 0404 agricultural biotechnology law ENCAPSULATION Crystallization Water content 030109 nutrition & dietetics SOLID DOSAGE FORM 04 agricultural and veterinary sciences 040401 food science chemistry Food Science Nuclear chemistry |
| Popis: | The objective of this work was to develop solid dosage forms to improve zinc nutrition in high-risk populations. Powders containing zinc (17 mg/g) were obtained through co-crystallization in sucrose matrix with high encapsulation efficiency (98%). Co-crystallized powders showed water activity (0.6) and moisture content (2.0%) values characteristic of good stability. Moreover, these products showed an infrared spectrum similar to that of sucrose, indicating that no chemical interactions took place between the matrix components. Co-crystallized powders showed excellent compactibility leading to suitably hard compacts at a low compression force (4.9 kN). Besides, tablets were obtained with optimal values of hardness (4.8 kgf) and low disintegration times ( |
| Databáze: | OpenAIRE |
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