Comparison Between Two Warm Ischemic Models in Experimental Liver Transplantation in Pigs
| Autor: | J.M Olea, F Pardo, J Baixaulí, Fernando Martínez Regueira, Jose Luis Hernandez-Lizoain, F. Rotellar, Javier A. Cienfuegos, A. Díez-Caballero, P.E Nwose, A. Espí |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Time Factors Swine medicine.medical_treatment Ischemia Liver transplantation Gastroenterology Transaminase Internal medicine medicine Animals Transplantation Homologous Aspartate Aminotransferases Liver injury Transplantation medicine.diagnostic_test business.industry Organ Preservation/methods Organ Preservation Liver/cytology/pathology medicine.disease Liver Transplantation Surgery medicine.anatomical_structure Liver Transplantation/physiology Liver Models Animal Prothrombin Time Prothrombin business Liver function tests Reperfusion injury Liver Circulation Artery |
| Zdroj: | Dadun. Depósito Académico Digital de la Universidad de Navarra instname |
| Popis: | Experimental models of warm ischemia in liver transplantation have been employed to study the mechanisms and treatment of ischemia reperfusion injury. METHODS: We compared a control group without (group A, n = 10) versus two models of warm ischemia of liver transplants in pigs: namely, occlusion of the hepatic artery and portal vein for 30 minutes (group B, n = 23) and extraction of the liver 60 minutes after cardiac arrest (group C, n = 5). Liver function tests, coagulation studies, and liver biopsies were performed during the first 24 hours post-liver transplant. RESULTS: Clamping of the hepatic vasculature in group B produced a significant liver injury compared with the control group: elevation of the ALT and an abnormal 1-hour post-revascularization biopsy similar to that observed in the cardiac arrest group C. The transaminase levels were lower among group A animals (P |
| Databáze: | OpenAIRE |
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