Human epididymis protein 4 and fetal lung maturity
| Autor: | Aslı Yarcı Gursoy, Gamze Sinem Caglar, Tuncay Kucukozkan, Hande Esra Koca, Arzu Bostanci Durmus, Betül Tokgöz Çakır, Sevilay Karahan, Tuba Candar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Amniotic fluid
Umbilical cord Andrology Fetal Organ Maturity Pregnancy medicine Humans Lung Respiratory Distress Syndrome Newborn Fetus Cesarean Section business.industry Infant Newborn Obstetrics and Gynecology Amniotic Fluid medicine.disease Cross-Sectional Studies medicine.anatomical_structure Cord blood Pediatrics Perinatology and Child Health Population study Female Lamellar body count business |
| Zdroj: | Journal of Perinatal Medicine. 50:219-224 |
| ISSN: | 1619-3997 0300-5577 |
| Popis: | Objectives To document the maternal and fetal cord blood levels of human epididymis protein 4 (HE-4) in term and preterm newborns in order to investigate the possible physiological role of HE-4 in fetal lung development. Methods This cross-sectional study was conducted in a university-affiliated hospital between April 2018 and September 2018. The study population consisted of cesarean section (C-section) deliveries after 24 weeks of pregnancy. Both maternal and umbilical cord HE-4 levels (mHE-4 and uHE-4, respectively) were measured using chemiluminescent microparticle immunoassay. Amniotic fluid was sampled from each case to determine the lamellar body count (LBC) as the gold standard test for lung maturation. All the parameters, including the uHE-4 levels, were compared between the term delivery (≥37 weeks) (n=52) and preterm delivery (24–37th weeks) (n=30) groups. The best cut-off value of uHE-4 was calculated for fetal lung maturity. Results There were no statistically significant differences between the groups regarding the demographic data. The mHE-4 levels did not statistically significantly differ between the groups (p>0.05) whereas the uHE-4 level of the preterm newborns was significantly higher than that of the term newborns (p Conclusions Although the exact physiological role of HE-4 has not yet been elucidated, this preliminary study supports the idea that HE-4 plays a role in fetal lung maturation to some extent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|