Penetration of diazepam and the non-peptide CCK antagonist, L-364, 718, into rat brain
| Autor: | O. J. Hodgson, R. G. L. Pullen |
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| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Pharmaceutical Science Peptide Pharmacology Devazepide chemistry.chemical_compound Pharmacokinetics Internal medicine medicine Animals Neurotransmitter Cholecystokinin chemistry.chemical_classification Benzodiazepinones Diazepam Antagonist Brain Rats Inbred Strains Penetration (firestop) Metabolism Rats Endocrinology chemistry medicine.drug |
| Zdroj: | Journal of Pharmacy and Pharmacology. 39:863-864 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/j.2042-7158.1987.tb05138.x |
| Popis: | Interest in the actions of the peptide cholecystokinin (CCK) has led to the design and synthesis of several non-peptide CCK antagonists, the most recent being that produced by Merck Sharp & Dohme and designated L-364, 718. This can be viewed as modified D-tryptophan linked to diazepam (1-methyl-3-(2-indoloyl)amino-5-phenyl-3H-1,4-benzodiazepin-2-one) 1. |
| Databáze: | OpenAIRE |
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