Metabolic observations in adult hypophosphatasia
| Autor: | William R. Beisel, Hyman Rosen, K. Frank Austen, E.G. Herndon |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
Adult
Nitrogen balance medicine.medical_specialty business.industry Hypophosphatasia chemistry.chemical_element Rickets General Medicine Calcium medicine.disease Medical Records Phosphoric Monoester Hydrolases chemistry.chemical_compound Phosphorylethanolamine Blood serum Endocrinology chemistry Metabolic Diseases Internal medicine Stilbestrol medicine Alkaline phosphatase Humans business |
| Zdroj: | The American journal of medicine. 29 |
| ISSN: | 0002-9343 |
| Popis: | A diagnosis of hypophosphatasia of the type which occurs in adults was established in a thirty-six year old white man who suffered an incomplete femoral fracture after minimal trauma. The diagnosis was established on the basis of consistently low serum alkaline phosphatase values, apparent absence of alkaline phosphatase activity in leukocytes, and an abnormally high urinary excretion of phosphorylethanolamine. In two prolonged metabolic balance studies during healing of the fracture it was noted that the patient was retaining calcium and phosphorus. The rate of retention of these minerals was not influenced by the administration of prednisone in three dosage levels or by stilbestrol. These drugs also failed to cause elevation of the low serum alkaline phosphatase, or to induce detectable alkaline phosphatase activity in leukocytes. The nitrogen balance varied with intake and the dosage of prednisone, and did not parallel the balance of calcium or phosphorus. |
| Databáze: | OpenAIRE |
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