Neural ECM and epilepsy
| Autor: | Grzegorz M. Wilczynski, Elodie Chabrol, Katarzyna Łukasiuk, Naiara Vazquez, Elizabeth M. Powell, Matthew C. Walker, Asla Pitkänen, Xavier Ekolle Ndode-Ekane, Alexander Dityatev, Stefanie Dedeurwaerdere |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Regulator
Long-term potentiation Matrix metalloproteinase drug therapy [Epilepsy] medicine.disease Interactome Epileptogenesis therapeutic use [Anticonvulsants] pathology [Epilepsy] physiology [Extracellular Matrix] Extracellular matrix Epilepsy Treatment targets metabolism [Receptors Urokinase Plasminogen Activator] medicine Animals drug effects [Extracellular Matrix] Humans drug effects [Receptors Urokinase Plasminogen Activator] ddc:610 Psychology metabolism [Epilepsy] Neuroscience |
| Zdroj: | Amsterdam [u.a.] : Elsevier, Progress in Brain Research 214, 229-262 (2014). doi:10.1016/B978-0-444-63486-3.00011-6 Brain Extracellular Matrix in Health and Disease / Pitkänen, Asla ; : Elsevier, 2014, ; ISSN: 00796123 ; ISBN: 9780444634863 ; doi:10.1016/B978-0-444-63486-3.00011-6 |
| DOI: | 10.1016/B978-0-444-63486-3.00011-6 |
| Popis: | Currently, there are about 20 antiepileptic drugs on market. Still, seizures in about 30% of patients with epilepsy are not adequately controlled, or the drugs cause quality-of-life-compromising adverse events. Importantly, there are no treatments to combat epileptogenesis, a process that leads to the development of epilepsy and its progression. To fill the gaps in the treatment of epilepsy, there is an urgent need for identification of novel treatment targets. Data emerging over the recent years have shown that different components of the extracellular matrix (ECM) contribute to many components of tissue reorganization during epileptogenesis and the ECM is also a major regulator of synaptic excitability. Here, we review the role of urokinase-type plasminogen activator receptor interactome, matrix metalloproteinases, tenascin-R, and LGI1 in epileptogenesis and ictogenesis. Moreover, the role of the ECM in epilepsy-related comorbidities is reviewed. As there is active development of new imaging methods, we also summarize the data available on imaging of the ECM in epilepsy. |
| Databáze: | OpenAIRE |
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