A sulphonoglycolipid from the fern Polypodium decumanum and its effect on the platelet activating-factor receptor in human neutrophils
| Autor: | M Vasange, Lars Bohlin, Wenche Rolfsen |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Magnetic Resonance Spectroscopy
Neutrophils Pharmaceutical Science Receptors Cell Surface Platelet Membrane Glycoproteins Pharmacology Platelet membrane glycoprotein Tritium Exocytosis Gas Chromatography-Mass Spectrometry Receptors G-Protein-Coupled chemistry.chemical_compound medicine Humans Platelet Activating Factor Receptor Calaguala Plants Medicinal biology Platelet-activating factor Plant Extracts Biological activity biology.organism_classification Mechanism of action chemistry Immunology lipids (amino acids peptides and proteins) medicine.symptom Platelet-activating factor receptor Glycolipids Antagonism Leukocyte Elastase |
| Zdroj: | The Journal of pharmacy and pharmacology. 49(5) |
| ISSN: | 0022-3573 |
| Popis: | The South American fern Polypodium decumanum, traditional name calaguala, has documented clinical use in oral treatment of skin disorders, including psoriasis. The inflammatory mediator platelet-activating factor (PAF), has been implicated in the pathogenesis of psoriasis. A constituent of a calaguala extract has been shown to have inhibitory activity in a PAF-induced exocytosis model in human neutrophils. The compound was identified as the sulphoquinovosyl diacylglycerol 1,2-di-O-palmitoyl-3-O-(6-sulpho-α-d-quinovopyranosyl)-glycerol by spectroscopic means. When subsequently studied in an in-vitro model for [3H]PAF binding in neutrophils from man the compound caused dose-dependent displacement of [3H]PAF from its receptor with an IC50 value of 2 μm. It is suggested that the compound acts through PAF receptor antagonism in intact human neutrophils. |
| Databáze: | OpenAIRE |
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