Multi-omics and male infertility status integration and future prospects
| Autor: | Savita Yadav, Virendra Singh, Ashima Sinha |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Proteomics 030219 obstetrics & reproductive medicine General Immunology and Microbiology 030232 urology & nephrology Genomics Computational biology Biology General Biochemistry Genetics and Molecular Biology Transcriptome 03 medical and health sciences 0302 clinical medicine Proteome Gene expression Humans Epigenetics Gene Infertility Male Epigenomics |
| Zdroj: | Frontiers in Bioscience. 9:375-394 |
| ISSN: | 1945-0524 1945-0516 |
| DOI: | 10.2741/s493 |
| Popis: | Within the cell, gene expression analysis is the key to gain information about different cellular and physiological events. The multifaceted route of fertilization is a combination of different processes, which include production, maturation and ejaculation of the sperm, its travel through the female genital tract, followed by the ultimate fusion of the fertile sperm with the egg. Early embryogenesis and gametogenesis as well as gene expression at tissue level and global gene silencing are under different levels of stringent epigenetic checks. Moreover, transcriptome (expressed segment of the genome in form of RNA) and the proteome (expressed set of genomic proteins) contribute uniformly to the overall cellular gene expression. In both normal and pathophysiological environments, this gene expression is altered across various levels viz., genome variations, post-transcriptional modifications, protein expression and post translational modifications. Consequently, more informative conclusions can be drawn through a new 'omics' approach of system biology, which takes into account all the genomics, epigenomics, proteomics, and metabolomics findings under one roof, thus computing the alterations in all the entities (genes, proteins, metabolites) concurrently. |
| Databáze: | OpenAIRE |
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