Distinct Pattern of Paracoccidioides lutzii, P. restrepiensis and P. americana Antigens Recognized by IgE in Human Paracoccidioidomycosis
| Autor: | Mario Augusto Ono, Zuleica Naomi Tano, Carla S. de O. Bredt, Adriane Lenhard-Vidal, Fernando Cezar-dos-Santos, João Paulo Assolini, Eiko Nakagawa Itano, Ayako Sano |
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| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Antigens Fungal biology 030306 microbiology Paracoccidioidomycosis Paracoccidioides lutzii Paracoccidioides General Medicine Specific igg Immunoglobulin E medicine.disease Applied Microbiology and Biotechnology Microbiology 03 medical and health sciences Antigen biology.protein medicine Humans Somatic antigen 030304 developmental biology |
| Zdroj: | Current Microbiology. 78:2608-2614 |
| ISSN: | 1432-0991 0343-8651 |
| DOI: | 10.1007/s00284-021-02508-7 |
| Popis: | Paracoccidioidomycosis (PCM) is caused by the fungi Paracoccidioides spp. The main antigens recognized by IgE are known for P. brasiliensis species complex, but not for P. lutzii. Current research investigated the major P. lutzii (LDR2) antigens recognized by IgE, in comparison to P. restrepiensis and P. americana (former P. brasiliensis species complex), besides IgG recognition. Cell-free antigens (CFA) from P. lutzii (LDR2), P. restrepiensis (B339) and P. americana (LDR3) were analyzed by ELISA and immunoblotting (IB) by detecting specific IgG and IgE from sera from patients with PCM presumable by P. brasiliensis species complex (n = 24). Additionally, somatic antigen (SA) was analyzed by IB. P. lutzii (LDR2) antigens showed significantly lower reactivity than P. restrepiensis (B339) and P. americana (LDR3) in ELISA for both IgE and IgG (p |
| Databáze: | OpenAIRE |
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