Effectiveness of Danning Tablet in patients with non-alcoholic fatty liver of damp-heat syndrome type: A multicenter randomized controlled trial
| Autor: | Jian-jie Chen, Huafeng Wei, Sheng-Fu You, Hong-Gang Gu, Lian-Jun Xing, Guang Ji, Pei-Yong Zheng, Lun-Gen Lu, Pei-Ting Zhu, Jian-gao Fan |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Blood lipids Anorexia Gastroenterology Body Mass Index law.invention Diagnosis Differential Double-Blind Method Randomized controlled trial law Internal medicine medicine Humans Medicine Chinese Traditional business.industry Fatty liver Middle Aged medicine.disease Lipids Ursodeoxycholic acid Surgery Fatty Liver Complementary and alternative medicine Female Liver function medicine.symptom business Phytotherapy Body mass index Drugs Chinese Herbal medicine.drug |
| Zdroj: | Journal of Chinese Integrative Medicine. 6:128-133 |
| ISSN: | 1672-1977 |
| DOI: | 10.3736/jcim20080205 |
| Popis: | Objective: To evaluate the efficacy and safety of Danning Tablet (DNT) in patients with non-alcoholic fatty liver disease (NAFLD) of damp-heat syndrome type. Methods: A multicenter, randomized, double-blinded and positive drug parallel controlled trial was performed. One hundred and thirty-five patients were enrolled into the study and divided into two groups: DNT-treated group (n=102) and ursodeoxycholic acid (UDCA)-treated group (n=33). Body mass index (BMI), principal symptoms, liver function, blood lipids, iconographic, and compositional parameters were measured before and after treatment, respectively. Results: In the two groups, BMI, distress in hepatic region, fatigue. anorexia, liver function, blood lipids and iconographic parameters were significantly improved and the improvements of BMI, distress in hepatic region were better in DNT-treated group than in UDCA-treated group. The histological study also showed that DNT had positive effect in treatment of NAFLD. Conclusion: DNT is an effective drug to treat patients with NAFLD of damp-heat syndrome type and is more effective than UDCA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|