Glycyrrhizin alleviates experimental allergic asthma in mice
Autor: | Indranil Bhattacharya, Balaram Ghosh, Sharad V. Gangal, Ulaganathan Mabalirajan, Arjun Ram, Amit K. Dinda, Moumita Das |
---|---|
Rok vydání: | 2006 |
Předmět: |
Male
medicine.medical_specialty Allergy Hydrocortisone Ovalbumin Immunology Specific Airway Conductance Immunoglobulin E chemistry.chemical_compound Mice Internal medicine medicine Immunology and Allergy Animals Anti-Asthmatic Agents Glycyrrhizin Asthma Pharmacology Mice Inbred BALB C biology business.industry Respiratory disease Anti-Inflammatory Agents Non-Steroidal respiratory system Allergens medicine.disease Glycyrrhizic Acid respiratory tract diseases Disease Models Animal Endocrinology chemistry biology.protein Bronchoconstriction Methacholine medicine.symptom business medicine.drug |
Zdroj: | International immunopharmacology. 6(9) |
ISSN: | 1567-5769 |
Popis: | Asthma is a chronic respiratory disease, the incidence of which is increasing globally. The existing therapy is inadequate and has many adverse effects. It needs a better therapeutic molecule preferably of natural origin, which has negligible or no adverse effects. In view of this, we evaluated Glycyrrhizin (GRZ), a major constituent of a plant Glycyrrhiza glabra, for its efficacy on asthmatic features in a mouse model of asthma. BALB/c mice were sensitized and challenged with ovalbumin (OVA) to develop the asthmatic features such as airway hyperresponsiveness: allergen induced airway constriction and airway hyperreactivity (AHR) to methacholine (MCh), and pulmonary inflammation. The mice were orally treated with GRZ (2.5, 5, 10 and 20 mg/kg) during or after OVA-sensitization and OVA-challenge to evaluate its protective or reversal effect, respectively on the above asthmatic features. The status of airway hyperresponsiveness was measured by monitoring specific airway conductance (SGaw) using a non-invasive method and the pulmonary inflammation was assessed by haematoxylin and eosin staining of lung sections. Several other parameters associated with asthma such as interleukin (IL)-4, IL-5 interferon-gamma (IFN-gamma), OVA-specific IgE, total IgG(2a) and cortisol were measured by ELISA. GRZ (5 mg/kg) markedly inhibited OVA-induced immediate airway constriction, AHR to MCh (p |
Databáze: | OpenAIRE |
Externí odkaz: |