Congenital Transmission of Trypanosoma cruzi in Argentina, Honduras, and Mexico: An Observational Prospective Study

Autor: Rubi Gamboa-Leon, Yves Carlier, Maria Luisa Matute, Elizabeth J. Howard, Jesús Gurubel Maldonado, Carine Truyens, Luz Gibbons, Pierre Buekens, Claudia Herrera, Fernando Althabe, Benjamín López, Maria Luisa Cafferata, María Cecilia Robles, Concepción Zúniga, Jaime H Del Cid, Olga Graiff, Dawn M. Wesson, Maria Jesus Ramirez-Sierra, Jackeline Alger, Sergio Sosa-Estani, Eric Dumonteil, Norma Bustamante, Laura Susana Lara, Jorge García, José M. Belizán, Alvaro Ciganda, Christian Valladares
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Adult
medicine.medical_specialty
Honduras -- epidemiology
030231 tropical medicine
030106 microbiology
Chagas Disease -- epidemiology -- transmission
Statistics
Nonparametric
law.invention
03 medical and health sciences
0302 clinical medicine
law
Pregnancy
Virology
Internal medicine
Genotype
parasitic diseases
medicine
Humans
Prospective Studies
Trypanosoma cruzi
Prospective cohort study
Genotyping
Polymerase chain reaction
Trypanosoma cruzi -- pathogenicity
biology
business.industry
Infant
Newborn
Sciences bio-médicales et agricoles
Fetal Blood -- parasitology
biology.organism_classification
medicine.disease
Infectious Diseases
Cord blood
biology.protein
Parasitology
Female
Disease Transmission
Infectious -- statistics & numerical data
Antibody
business
Mexico -- epidemiology
Zdroj: The American journal of tropical medicine and hygiene, 98 (2
Popis: Compared with South America, there is a lack of epidemiologic studies about the risk of congenital transmission of Trypanosoma cruzi in Central America and Mexico. It has been suggested that T. cruzi genotypes might differ by region and that congenital transmission might vary according to the parasite's genotype. Our objective was to compare T. cruzi congenital transmission rates in three countries. We performed an observational prospective study in 2011-2014 enrolling women at delivery in one hospital in Argentina, two hospitals in Honduras, and two hospitals in Mexico. Congenital T. cruzi infection was defined as the presence of one or more of the following criteria: presence of parasites in cord blood (direct parasitological microscopic examination) with positive polymerase chain reaction (PCR) in cord blood, presence of parasites in infant's blood at 4-8 weeks (direct parasitological microscopic examination), and persistence of T. cruzi-specific antibodies at 10 months, as measured by at least two tests. Among 28,145 enrolled women, 347 had at least one antibody rapid test positive in cord blood and a positive enzyme-linked immunosorbent assay in maternal blood. PCR in maternal blood was positive in 73.2% of the cases, and genotyping identified a majority of non-TcI in the three countries. We found no (0.0%; 95% confidence interval [CI]: 0.0, 2.0) confirmed congenital case in Honduras. Congenital transmission was 6.6% (95% CI: 3.1, 12.2) in Argentina and 6.3% (95% CI: 0.8, 20.8) in Mexico. Trypanosoma cruzi non-TcI predominated and risks of congenital transmission were similar in Argentina and Mexico.
info:eu-repo/semantics/published
Databáze: OpenAIRE
Externí odkaz: