Arynes as synthetic linchpins towards the construction of diversely functionalized natural product skeletons

Autor:	R. Bharath Krishna, Shirin Hanna Moncy, Chithra Mohan
Rok vydání:	2023
Předmět:	Organic Chemistry Physical and Theoretical Chemistry Biochemistry
Zdroj:	Organic & Biomolecular Chemistry. 21:479-488
ISSN:	1477-0539 1477-0520
DOI:	10.1039/d2ob01975b
Popis:	Arynes are a privileged class of reactive intermediates in synthetic organic chemistry, and their unusual reactivities have been the subject of engrossing research interest. Recently, there are many reports on novel aryne-based synthetic innovations as a linchpin approach to accomplish the total synthesis of structurally diverse natural products or their derivatives in a racemic and enantiopure fashion. This review provides an overview of the literature on synthetic strategies, employing arynes as crucial intermediates to construct architecturally intriguing bioactive natural products/derivatives in a period of 2019 to 2022. This study highlights the need to investigate the effective synthesis and search for new biological uses of highly functionalized natural product skeletons.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f6afecd9f974f30bc4af7bfd82f5ed https://doi.org/10.1039/d2ob01975b Zobrazit plný text záznamu