MiR-135a-5p Is Critical for Exercise-Induced Adult Neurogenesis
| Autor: | Francesco Nicassio, Matteo Jacopo Marzi, Davide De Pietri Tonelli, Tara L. Walker, Alexandra Pötzsch, Gerd Kempermann, Clarissa Braccia, Meritxell Pons-Espinal, Klaus Fabel, Andrea Armirotti, Caterina Gasperini |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Aging biosynthesis [MicroRNAs] metabolism [Neural Stem Cells] Hippocampal formation Biochemistry p38 Mitogen-Activated Protein Kinases chemistry.chemical_compound Mice 0302 clinical medicine biosynthesis [Intercellular Signaling Peptides and Proteins] Neural Stem Cells Lateral Ventricles Inositol Cognitive decline Stem Cell Niche lcsh:QH301-705.5 Mice Knockout lcsh:R5-920 Neurogenesis Intracellular Signaling Peptides and Proteins Cell biology Adult Stem Cells Intercellular Signaling Peptides and Proteins lcsh:Medicine (General) cytology [Lateral Ventricles] Physical exercise Biology metabolism [Adult Stem Cells] Article 03 medical and health sciences Downregulation and upregulation Physical Conditioning Animal microRNA Genetics Animals Humans ddc:610 metabolism [Aging] biosynthesis [p38 Mitogen-Activated Protein Kinases] Cell Proliferation Dentate gyrus metabolism [Lateral Ventricles] Cell Biology MicroRNAs 030104 developmental biology chemistry lcsh:Biology (General) Gene Expression Regulation biosynthesis [Intracellular Signaling Peptides and Proteins] 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Stem cell reports 12(6), 1298-1312 (2019). doi:10.1016/j.stemcr.2019.04.020 Stem Cell Reports, Vol 12, Iss 6, Pp 1298-1312 (2019) |
| ISSN: | 2213-6711 |
| Popis: | Summary: Physical exercise stimulates adult hippocampal neurogenesis and is considered a relevant strategy for preventing age-related cognitive decline in humans. The underlying mechanisms remains controversial. Here, we show that exercise increases proliferation of neural precursor cells (NPCs) of the mouse dentate gyrus (DG) via downregulation of microRNA 135a-5p (miR-135a). MiR-135a inhibition stimulates NPC proliferation leading to increased neurogenesis, but not astrogliogenesis, in DG of resting mice, and intriguingly it re-activates NPC proliferation in aged mice. We identify 17 proteins (11 putative targets) modulated by miR-135 in NPCs. Of note, inositol 1,4,5-trisphosphate (IP3) receptor 1 and inositol polyphosphate-4-phosphatase type I are among the modulated proteins, suggesting that IP3 signaling may act downstream miR-135. miR-135 is the first noncoding RNA essential modulator of the brain's response to physical exercise. Prospectively, the miR-135-IP3 axis might represent a novel target of therapeutic intervention to prevent pathological brain aging. : Pons-Espinal, Gasperini, and colleagues report that running induces NPC proliferation and neurogenesis via downregulation of miR-135a-5p in the mouse hippocampus. Remarkably, downregulation of miR-135a stimulates proliferation in the hippocampus of aged mice. ITPR1 and INPP4A, involved in IP3 signaling, are modulated by miR-135 in NPCs. Prospectively, therapeutic exploitation of the miR-135-IP3 axis might represent a novel intervention strategy for successful aging. Keywords: adult neurogenesis, running, aging, miR-135a, inositol 1,4,5-trisphosphate (IP3) pathway, ITPR1, INPP4A |
| Databáze: | OpenAIRE |
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