Outcomes of Bleomycin-based electrochemotherapy in patients with repeated loco-regional recurrences of vulvar cancer
| Autor: | Daniela Turoli Scd, Antonio Cappello, Davide Strippoli, Maria Grazia Pezzotta, Silvia Corso, Giuseppe Loverro, Costantino Mangioni, Antonio Pellegrino, Massimo Tartagni, Gianluca Raffaello Damiani |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Electrochemotherapy Stage ii Bleomycin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Quality of life Surveys and Questionnaires Humans Medicine Radiology Nuclear Medicine and imaging In patient Stage (cooking) Aged Aged 80 and over Antibiotics Antineoplastic Vulvar Neoplasms business.industry Palliative Care Cancer Hematology General Medicine Middle Aged Vulvar cancer medicine.disease Surgery Treatment Outcome 030104 developmental biology Oncology chemistry 030220 oncology & carcinogenesis Injections Intravenous Quality of Life Female Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Acta Oncologica. 55:619-624 |
| ISSN: | 1651-226X 0284-186X |
| DOI: | 10.3109/0284186x.2015.1117134 |
| Popis: | Objective To evaluate the safety, local tumor efficacy and relief of symptoms of electrochemotherapy (ECT) treatment in patients affected by recurrence of vulvar cancer (VC), unsuitable for standard treatments. Methods Ten patients were recruited with histological diagnosis of recurrence of VC. Intravenous bleomycin was injected, after an accurate mapping of all lesions and ECT was performed. Response to therapy was evaluated and quality of life (QoL) was evaluated via questionnaires. Results Diagnosis stage of primary tumors, according to the FIGO system, was: four patients respectively at stage IB (40%), and at stage II (40%), one patient at stage IIIA (10%), one patient with Paget cancer (10%). Mean age was 76 years (SD ± 7) at time of enrollment. Eight patients (80%) were previously submitted to surgery and/or radio-chemotherapy. Mean treatment time was 20 (range 10-20) min. After a median follow-up of 12 (3-22) months, six patients (60%) were alive. Conclusions Objective responses (ORs) with local control of the tumor were obtained in 80%. After a mean follow-up of 12 (3-22) months six patients (60%) were alive. The favorable outcome of this study, indicates that ECT is a reliable treatment option that may improve their functioning, thus enhancing the care provided in the palliative setting. |
| Databáze: | OpenAIRE |
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