Adipose tissue as a target for second-generation (atypical) antipsychotics: A molecular view
| Autor: | Vitor Ferreira, Diana Grajales, Ángela M. Valverde |
|---|---|
| Přispěvatelé: | Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Comunidad de Madrid, European Commission, Instituto de Salud Carlos III |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Medicina Adipocytes White Adipose tissue Bioinformatics 03 medical and health sciences chemistry.chemical_compound Sex Factors 0302 clinical medicine Management of schizophrenia Adipocyte Prevalence medicine Humans Antipsychotics In patient Clozapine Molecular Biology Metabolic Syndrome Adipocyte differentiation business.industry Cell Differentiation Mesenchymal Stem Cells Thermogenesis Lipid metabolism Cell Biology medicine.disease 3. Good health Adipocytes Brown 030104 developmental biology Neuropsychiatric disorder chemistry Schizophrenia Female Browning business 030217 neurology & neurosurgery Dyslipidemia Antipsychotic Agents |
| Zdroj: | Biblos-e Archivo: Repositorio Institucional de la UAM Universidad Autónoma de Madrid Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids Biblos-e Archivo. Repositorio Institucional de la UAM instname Digital.CSIC. Repositorio Institucional del CSIC |
| ISSN: | 1388-1981 |
| DOI: | 10.1016/j.bbalip.2019.158534 |
| Popis: | Schizophrenia is a neuropsychiatric disorder that chronically affects 21 million people worldwide. Second-generation antipsychotics (SGAs) are the cornerstone in the management of schizophrenia. However, despite their efficacy in counteracting both positive and negative symptomatology of schizophrenia, recent clinical observations have described an increase in the prevalence of metabolic disturbances in patients treated with SGAs, including abnormal weight gain, hyperglycemia and dyslipidemia. While the molecular mechanisms responsible for these side-effects remain poorly understood, increasing evidence points to a link between SGAs and adipose tissue depots of white, brown and beige adipocytes. In this review, we survey the present knowledge in this area, with a particular focus on the molecular aspects of adipocyte biology including differentiation, lipid metabolism, thermogenic function and the browning/beiging process. This work was funded by H2020 Marie Skłodowska-Curie ActionsITN-TREATMENT (Grant Agreement 721236, European Commission). We also acknowledge grants RTI2018-094052-B-100 (MICINN/FEDER, Spain), S2017/BMD-3684 MOIR2-CM (Comunidad de Madrid, Spain) and CIBERdem (ISCIII, Spain). |
| Databáze: | OpenAIRE |
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