A Middle-Aged Enzyme Still in Its Prime: Recent Advances in the Field of Cutinases
| Autor: | Maria Dimarogona, Efstratios Nikolaivits, Maria Kanelli, Evangelos Topakas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
0301 basic medicine Cutinase crystal structure biocatalysis Biology lcsh:Chemical technology 01 natural sciences Catalysis lcsh:Chemistry 03 medical and health sciences 010608 biotechnology depolymerization lcsh:TP1-1185 Physical and Theoretical Chemistry plastics degradation cutinase surface functionalization chemistry.chemical_classification ester synthesis 030104 developmental biology Enzyme Biochemistry chemistry lcsh:QD1-999 polymerization polyester hydrolysis |
| Zdroj: | Catalysts, Vol 8, Iss 12, p 612 (2018) |
| ISSN: | 2073-4344 |
| Popis: | Cutinases are α/β hydrolases, and their role in nature is the degradation of cutin. Such enzymes are usually produced by phytopathogenic microorganisms in order to penetrate their hosts. The first focused studies on cutinases started around 50 years ago. Since then, numerous cutinases have been isolated and characterized, aiming at the elucidation of their structure–function relations. Our deeper understanding of cutinases determines the applications by which they could be utilized; from food processing and detergents, to ester synthesis and polymerizations. However, cutinases are mainly efficient in the degradation of polyesters, a natural function. Therefore, these enzymes have been successfully applied for the biodegradation of plastics, as well as for the delicate superficial hydrolysis of polymeric materials prior to their functionalization. Even though research on this family of enzymes essentially began five decades ago, they are still involved in many reports; novel enzymes are being discovered, and new fields of applications arise, leading to numerous related publications per year. Perhaps the future of cutinases lies in their evolved descendants, such as polyesterases, and particularly PETases. The present article reviews the biochemical and structural characteristics of cutinases and cutinase-like hydrolases, and their applications in the field of bioremediation and biocatalysis. |
| Databáze: | OpenAIRE |
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