New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity
| Autor: | Wafaa S. Ahmed, Manal M. Hamed, Rabab A. El-Dib, Mona A. Mohamed |
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| Rok vydání: | 2009 |
| Předmět: |
HepG2
Stereochemistry Duranta Molecular Sequence Data Ethyl acetate Saponin Pharmaceutical Science Article Analytical Chemistry lcsh:QD241-441 Terpene chemistry.chemical_compound lcsh:Organic chemistry Triterpene Duranta repens triterpene saponins durantanin IV and V brine shrimp Cell Line Tumor Verbenaceae Drug Discovery Carbohydrate Conformation Animals Humans Physical and Theoretical Chemistry Nuclear Magnetic Resonance Biomolecular Oleanolic acid chemistry.chemical_classification Chloroform Molecular Structure Traditional medicine biology Organic Chemistry Saponins biology.organism_classification Antineoplastic Agents Phytogenic Triterpenes Plant Leaves Carbohydrate Sequence chemistry Chemistry (miscellaneous) Molecular Medicine Artemia Drug Screening Assays Antitumor |
| Zdroj: | Molecules, Vol 14, Iss 5, Pp 1952-1965 (2009) Molecules; Volume 14; Issue 5; Pages: 1952-1965 Molecules |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules14051952 |
| Popis: | From the leaves of Duranta repens (Verbenaceae) two new triterpene saponins, named durantanin IV (1) and V (2)were isolated.In addition, ten known compounds were isolated, namely a bidesmosidic saponin, oleanolic acid, three phenylethanoids and five flavonoids. All metabolites were isolated for the first time from this genus except for 3 (oleanolic acid) and 7 (E/Z acteoside). The structures were determined mainly by spectroscopic methods (UV, IR, HRESI-MS, (1)H-, (13)C-NMR, (1)H-(1)H COSY, HSQC and HMBC). Cytotoxic screening of the chloroform, ethyl acetate and methanol extracts was carried out on brine shrimps. In addition, the investigated methanol extract and compounds 1, 2 and 7 showed significant cytotoxic activity against a HepG2 cell line. |
| Databáze: | OpenAIRE |
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