Supplementation of oligofructose, but not sucralose, decreases high-fat diet induced body weight gain in mice independent of gustducin-mediated gut hormone release
| Autor: | Laurien Vancleef, Bert Avau, Ricard Farré, Kristin Verbeke, Inge Depoortere, Sandra Steensels, Leen Cools |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Sucralose Sucrose Enteroendocrine Cells Adipose tissue Oligosaccharides 030209 endocrinology & metabolism Biology Diet High-Fat Weight Gain Fat pad Receptors G-Protein-Coupled 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Glucagon-Like Peptide 1 Internal medicine medicine Animals Peptide YY Transducin chemistry.chemical_classification Mice Knockout Intestinal permeability digestive oral and skin physiology Fatty acid Gustducin medicine.disease Ghrelin Gastrointestinal Tract Mice Inbred C57BL 030104 developmental biology Endocrinology chemistry Sweetening Agents Dietary Supplements Insulin Resistance Food Science Biotechnology |
| Zdroj: | Molecular nutritionfood research. 61(3) |
| ISSN: | 1613-4133 |
| Popis: | cope Entero-endocrine cells (EECs) sense nutrients through taste receptors similar to those on the tongue. Sweet -and fatty acid taste (FFAR) receptors coupled to the gustatory G-protein, gustducin, on EECs play a role in gut hormone release. We studied if supplementation of artificial (sucralose) or prebiotic (oligofructose; OFS) sweeteners target gustducin-mediated signaling pathways to alter gut hormone release and reduce obesity-associated disorders. Methods and results Wild type (WT) and α-gustducin knockout (α-gust−/−) mice were fed a high-fat diet and gavaged once daily (8 weeks) with water or equisweet concentrations of sweeteners. OFS but not sucralose decreased body weight gain (-19±3%, P |
| Databáze: | OpenAIRE |
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