Circulating ANGPTL8 levels and risk of kidney function decline: Results from the 4C Study

Autor: Yong Chen, Xi Chen, Gang Yuan, Xinrong Zhou, Shuhong Hu, Xiaoyu Meng, Shiying Shao, Junhui Xie, Huajie Zou, Yongping Xu, Xuefeng Yu, Yan Yang, Jianhua Zhang, Zhelong Liu, Tingting Du, Wenjun Li, Wentao He, Delin Ma, Benping Zhang, Danpei Li
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Time Factors
Peptide Hormones
Endocrinology
Diabetes and Metabolism
030204 cardiovascular system & hematology
Kidney
Gastroenterology
0302 clinical medicine
Risk Factors
eGFR
Medicine
Longitudinal Studies
Kidney function decline
Original Investigation
0303 health sciences
Hazard ratio
Middle Aged
ANGPTL8
Up-Regulation
Hospitalization
Quartile
Cohort
Disease Progression
Female
Kidney Diseases
Cardiology and Cardiovascular Medicine
Glomerular Filtration Rate
Adult
China
medicine.medical_specialty
Renal function
Risk Assessment
03 medical and health sciences
Angiopoietin-Like Protein 8
Diabetes mellitus
Internal medicine
Humans
Diseases of the circulatory (Cardiovascular) system
Aged
Retrospective Studies
030304 developmental biology
business.industry
Proportional hazards model
medicine.disease
4C Study
Relative risk
RC666-701
business
Biomarkers
Kidney disease
Zdroj: Cardiovascular Diabetology
Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-8 (2021)
ISSN: 1475-2840
Popis: Background ANGPTL8, an important regulator of lipid metabolism, was recently proven to have additional intracellular and receptor-mediated functions. This study aimed to investigate circulating levels of ANGPTL8 and its potential association with the risk of kidney function decline in a cohort study. Methods We analysed 2,311 participants aged 40 years old and older from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. Kidney function decline was defined as an estimated glomerular filtration rate (eGFR) less than 60 mL per minute per 1.73 m2 of body surface area, a decrease in eGFR of ≥ 30% from baseline, chronic kidney disease (CKD)-related hospitalization or death, or end-stage renal disease. The association between baseline ANGPTL8 levels and kidney function decline was assessed using multivariable-adjusted Cox proportional hazards models, and inverse possibility of treatment weight (IPTW) was utilized to prevent overfitting. Results There were 136 (5.9%) cases of kidney function decline over a median of 3.8 years of follow-up. We found that serum ANGPTL8 levels at baseline were elevated in individuals with kidney function decline compared to those without kidney function decline during follow-up (718.42 ± 378.17 vs. 522.04 ± 283.07 pg/mL, p Conclusions Participants with higher circulating ANGPTL8 levels were at increased risk for kidney function decline, highlighting the importance of future studies addressing the pathophysiological role of ANGPTL8 in CKD.
Databáze: OpenAIRE
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