Antimycobacterial Activity of Rifampin Under In Vitro and Simulated In Vivo Conditions
| Autor: | G. P. Kubica, C. L. Woodley, K. D. Stottmeier |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
medicine.drug_class
Drug Storage Antibiotics Antitubercular Agents Pharmacology Biology Antimycobacterial Models Biological General Biochemistry Genetics and Molecular Biology Mycobacterium Microbiology Agar plate Drug Stability In vivo polycyclic compounds Isoniazid medicine General Pharmacology Toxicology and Pharmaceutics General Immunology and Microbiology Antimicrobial Agents and Chemotherapy Cycloserine Drug Resistance Microbial Mycobacterium tuberculosis General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses Ethionamide Rifampin Dialysis Rifampicin medicine.drug |
| Zdroj: | Applied Microbiology. 17:861-865 |
| ISSN: | 0003-6919 |
| DOI: | 10.1128/am.17.6.861-865.1969 |
| Popis: | Minimal inhibitory concentrations of rifampin for different species of mycobacteria were determined in 7H-10 agar medium and Lowenstein-Jensen egg medium. When rifampin was incorporated into egg medium, approximately 90% of its activity was lost. The stability of rifampin was tested during storage at different temperatures and concentrations. When tested in agar medium, a combination of isoniazid (INH) and rifampin inhibited multiple drug-resistant strains of Mycobacterium intracellulare, but under simulated in vivo conditions the drugs did not eliminate these same organisms. Drug-resistant mutants of M. intracellulare multiplied during an 8-day period when exposed 10 hr daily to the INH-rifampin regimen. However, combinations of rifampin and INH reduced drug-resistant mycobacterial populations by 99%, an effect which could not be enhanced by the addition of either erythromycin, ethionamide, or cycloserine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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