Interleukin 28B rs12979860 (CT/TT) genotype is associated with milder hepatic damage in the natural evolution of HCV/HIV coinfection
| Autor: | Raúl Ortiz de Lejarazu, Rosa Arnaiz, Concha de la Fuente, Concepción Nieto, Carmen Hinojosa, Maria Ángeles Jiménez Sousa, Jesus F. Bermejo-Martin, Isabel Gilabert, Jose Manuel González, Ana Ma Loma |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Genotype Hepatitis C virus Immunology HIV Infections Hepacivirus Biology medicine.disease_cause Polymorphism Single Nucleotide Virus Virology Antiretroviral Therapy Highly Active medicine Humans Aspartate Aminotransferases Genotyping Retrospective Studies Coinfection Interleukins virus diseases HIV Alanine Transaminase Cell Biology Middle Aged medicine.disease Hepatitis C Interleukin 28B Liver Multivariate Analysis Linear Models Liver function Interferons Viral load |
| Zdroj: | Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 33(1) |
| ISSN: | 1557-7465 |
| Popis: | Hepatitis C virus (HCV)/human immunodefficiency virus (HIV) coinfection is a major health problem, affecting mostly to individuals with exposure to blood products, as hemophiliacs or intravenous drug users, or those exposed to high-risk sexual practices. Genotyping of interleukin 28B (IL-28B) rs12979860 polymorphism is a useful tool for guiding therapeutic decisions in this disease. On the contrary, there is not enough information on the pathogenic role of this polymorphism in the natural history of the disease. The objective of this study is to describe the relationships between the CT/TT genotype of this polymorphism with viral loads and also with a number of biomarkers of liver function in coinfected patients naïve for treatment for HCV. Seventy-five HCV/HIV coinfected patients were retrospectively recruited in our Hospital from 2010 to 2011. Logistic regression analysis adjusting by [Age], [Sex], [HCV viral genotype], [HCV viral load], [HIV viral load], and [CD4 T cells levels] revealed the IL-28B rs12979860 (CT/TT) genotype as a protective factor against alanine aminotransferase (ALT) levels (100 IU/L), aspartate aminotransferase (AST) levels (75 IU/L), and AST-to-platelet ratio index (APRI) score for liver fibrosis (1.5) [OR, (95% CI), p]: ALT [0.026 (0.001-0.576) 0.021]; AST [0.001 (0.000-0.297) 0.019]; APRI [0.031 (0.002-0.41) 0.008]. Stepwise regression analysis considering the same adjusting variables showed the same results. In consequence, the IL-28B rs12979860 (CT/TT) genotype, which is a marker of poor response to HCV treatment, could be mediating on the contrary a certain protective effect against the hepatic damage caused by this virus in patients coinfected by HIV. |
| Databáze: | OpenAIRE |
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