Impact of rapid multiplex PCR on management of antibiotic therapy in COVID-19-positive patients hospitalized in intensive care unit
| Autor: | Lotfi Chemali, Jean-François Timsit, Laurence Armand-Lefevre, Emilie Rondinaud, Philippe Montravers, Lucie Le Fevre, Brice Lortat-Jacob, Camille d’Humières, Naouale Maataoui, Alexy Tran Dinh, Juliette Patrier, Mehdi Marzouk, Etienne Ruppé |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) medicine.medical_specialty medicine.drug_class 030106 microbiology Antibiotics medicine.disease_cause law.invention Antimicrobial Stewardship 03 medical and health sciences 0302 clinical medicine Medical microbiology law Internal medicine Multiplex polymerase chain reaction medicine Humans 030212 general & internal medicine Medical prescription Aged Retrospective Studies Antibiotic stewardship Bacteria SARS-CoV-2 Coinfection business.industry Brief Report COVID-19 Bacterial Infections General Medicine Middle Aged Multiplex PCR medicine.disease Intensive care unit Anti-Bacterial Agents Hospitalization Intensive Care Units Pneumonia Infectious Diseases Superinfection Female business Multiplex Polymerase Chain Reaction |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/s10096-021-04213-6 |
| Popis: | Because the diagnosis of co/superinfection in COVID-19 patients is challenging, empirical antibiotic therapy is frequently initiated until microbiological analysis results. We evaluated the performance and the impact of the BioFire® FilmArray® Pneumonia plus Panel on 112 respiratory samples from 67 COVID-19 ICU patients suspected of co/superinfections. Globally, the sensitivity and specificity of the test were 89.3% and 99.1%, respectively. Positive tests led to antibiotic initiation or adaptation in 15% of episodes and de-escalation in 4%. When negative, 28% of episodes remained antibiotic-free (14% no initiation, 14% withdrawal). Rapid multiplex PCRs can help to improve antibiotic stewardship by administering appropriate antibiotics earlier and avoiding unnecessary prescriptions. Supplementary Information The online version contains supplementary material available at 10.1007/s10096-021-04213-6. |
| Databáze: | OpenAIRE |
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