Regional lymph node metastases in cutaneous melanoma: a single-center analysis from southeast europe
| Autor: | Nenad Petrov, Nenad Stepic, Marija Radulović, Zeljko Mijuskovic, Ljiljana Jauković, Z Nikolic, Milica Rajović, L. Kandolf Sekulovic |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Skin Neoplasms Standard of care Sentinel lymph node Nodal staging Single Center 03 medical and health sciences 0302 clinical medicine Biopsy medicine Humans 030212 general & internal medicine Melanoma Lymph node medicine.diagnostic_test business.industry medicine.disease Europe medicine.anatomical_structure Lymphatic Metastasis 030220 oncology & carcinogenesis Cutaneous melanoma Surgery Radiology business |
| Zdroj: | Scandinavian Journal of Surgery. 110:498-503 |
| ISSN: | 1799-7267 1457-4969 |
| Popis: | Objective: Sentinel lymph node biopsy is the standard of care for nodal staging in clinically node-negative melanoma patients. Our goal was to present 10-year results of sentinel lymph node biopsy at our institution and to evaluate the clinicopathologic factors as potential predictors of sentinel lymph node and non-sentinel lymph node metastatic involvement in patients with cutaneous melanoma. Methods: We have analyzed clinicopathologic and lymphoscintigraphic characteristics in 420 patients with cutaneous melanoma who underwent sentinel lymph node biopsy between 2010 and 2019. In addition, we have examined the results of group of patients with positive sentinel lymph node biopsy undergoing complete lymph node dissection. Results: The overall detection rate of sentinel lymph node biopsies was 97.1%, of which 18.8% was metastatic. Drainage to one regional basin was seen in 345 patients (83.1%) and to multiple drainage regions in 71 patients (17%). In-transit lymph nodes were detected in 20 patients. On univariate logistic regression analysis, male gender, primary tumor thickness with nodular histology, acral location, presence of ulceration, and the number of nodes harvested were significantly associated with sentinel lymph node biopsy status ( p Conclusions: In addition to the well-established primary tumor thickness as a predictor of sentinel lymph node biopsy positivity, we observed acral location and nodular melanoma subtype to significantly enhance the risk of metastases in sentinel lymph node(s). Primary tumor histology and number of nodes harvested were the only statistically significant variables predicting the non-sentinel lymph node status on multivariate analysis. Lymphoscintigraphy imaging characteristics were not significantly associated with sentinel lymph node status. |
| Databáze: | OpenAIRE |
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