Functional Connectivity Between the Posterior Default Mode Network and Parahippocampal Gyrus Is Disrupted in Older Adults with Subjective Cognitive Decline and Correlates with Subjective Memory Ability
| Autor: | Geetanjali Murari, Susan Vandermorris, Namita Sharma, J. Jean Chen, Linda Mah, Nicolaas Paul L.G. Verhoeff, Nathan Herrmann |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Audiology Gyrus Cinguli Temporal lobe 03 medical and health sciences Diagnostic Self Evaluation 0302 clinical medicine Neural Pathways medicine Humans Cognitive Dysfunction Cognitive decline Default mode network Aged Memory Disorders Forgetting 030214 geriatrics medicine.diagnostic_test Resting state fMRI business.industry General Neuroscience Functional Neuroimaging Default Mode Network General Medicine Middle Aged Magnetic Resonance Imaging Temporal Lobe Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Posterior cingulate Parahippocampal Gyrus Female Geriatrics and Gerontology Functional magnetic resonance imaging business 030217 neurology & neurosurgery Parahippocampal gyrus |
| Zdroj: | Journal of Alzheimer's disease : JAD. 82(1) |
| ISSN: | 1875-8908 |
| Popis: | Background: Subjective cognitive decline (SCD) is associated with increased risk of developing Alzheimer’s disease (AD). However, the underlying mechanisms for this association remain unclear. Neuroimaging studies suggest the earliest AD-related changes are large-scale network disruptions, beginning in the posterior default mode (pDMN) network. Objective: To examine the association between SCD and pDMN network connectivity with medial temporal lobe (MTL) regions using resting-state functional magnetic resonance imaging. Methods: Forty-nine participants with either SCD (n = 23, 12 females; mean age: 70.7 (5.5)) or who were cognitively unimpaired (CU; n = 26, 16 females, mean age: 71.42 (7.3)) completed the Memory Functioning Questionnaire, a measure of subjective memory, and underwent resting state functional MRI at 3 Tesla. Functional connectivity between the posterior cingulate cortex (PCC), as the key pDMN node, and MTL regions were compared between SCD and CU groups. Further, the association between pDMN-MTL connectivity and the Frequency of Forgetting subscale of the Memory Functioning Questionnaire was examined. Results: Connectivity between the PCC-MTL was observed in the CU group but was absent in SCD (t(47) = 2.69, p = 0.01). Across all participants, self-perception of frequency of forgetting, but not objective memory, was strongly correlated with connectivity between the PCC-left parahippocampal gyrus (r = 0.43, p = 0.002). Conclusion: These findings support the hypothesis that increased AD risk in SCD may be mediated by disrupted pDMN-parahippocampal connectivity. In addition, these findings suggest that frequency of forgetting may serve as a potential biomarker of SCD due to incipient AD. |
| Databáze: | OpenAIRE |
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