Anti-transglutaminase 6 autoantibody development in children with celiac disease correlates with duration of gluten exposure

Autor: Stefano Martelossi, Nicola Salce, Tarcisio Not, Fabiana Ziberna, Pascale Aeschlimann, Giorgio Cozzi, Daniel Aeschlimann, Luigina De Leo, Serena Vatta, Alessandro Ventura, Marios Hadjivassiliou
Přispěvatelé: De Leo, Luigina, Aeschlimann, Daniel, Hadjivassiliou, Mario, Aeschlimann, Pascale, Salce, Nicola, Vatta, Serena, Ziberna, Fabiana, Cozzi, Giorgio, Martelossi, Stefano, Ventura, Alessandro, Not, Tarcisio
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Delayed Diagnosis
Time Factors
Tissue transglutaminase
Disease
medicine.disease_cause
Pediatrics
Autoimmunity
0302 clinical medicine
Isoantibodies
Risk Factors
Medicine
Child
chemistry.chemical_classification
biology
Gastroenterology
Perinatology and Child Health
Treatment Outcome
Child
Preschool
Gluten-free diet
Female
030211 gastroenterology & hepatology
Antibody
Adolescent
Glutens
RJ
Enzyme-Linked Immunosorbent Assay
Diet
Gluten-Free
03 medical and health sciences
RZ
Humans
Neurological disorder
Retrospective Studies
Transglutaminases
business.industry
Neurological disorders
Transglutaminase 6
Pediatrics
Perinatology and Child Health
Autoantibody
Case-control study
Infant
Gluten
Diet
Celiac Disease
chemistry
Case-Control Studies
Immunology
biology.protein
Nervous System Diseases
business
Biomarkers
030217 neurology & neurosurgery
Follow-Up Studies
ISSN: 0277-2116
Popis: Objectives: Antibodies against transglutaminase 6 (anti-TG6) have been implicated in neurological manifestations in adult patients with genetic-gluten intolerance and it is unclear whether autoimmunity to TG6 develops following prolonged gluten exposure. We measured the anti-TG6 in children with celiac disease (CD) at the diagnosis time to establish a correlation between these autoantibodies and the duration of gluten exposure. We investigated a correlation between anti-TG6 and the presence of neurological disorders. Methods: Anti-TG6 (IgA/IgG) were measured by ELISA in sera of children with biopsy-proven CD and of children suffering from gastrointestinal disorders. CD-patients positive for anti-TG6 were retested after 2 years of gluten-free diet (GFD). Results: We analyzed the sera of 274 CD-children and of 121 controls. Anti-TG6 were detected in 68/274 (25%) CD-patients and in 19/121 (16%) controls, with significant difference between the two groups (p=0.04). None of the CD-patients and of the controls testing positive for anti-TG6 were suffering from neurological disorders. Eleven/18 (61%) CD-patients with other autoimmune diseases were positive for anti-TG6. In CD-patients a significant correlation between the gluten exposure before the CD-diagnosis and anti-TG6 concentration was found (p=0.006 for IgA; p
Databáze: OpenAIRE
Externí odkaz: