High levels of proinflammatory cytokines IL-6, IL-8, TNF-Α, IL-23, and IFN- in Tunisian patients with type 1 autoimmune hepatitis

Autor:	Radhia Kochkar, Aymen Tezeghdenti, Maroua Chaouali, Ezzedine Ghazouani, Besma Yacoubi-Oueslati, Mouna Ben Azaiez
Rok vydání:	2020
Předmět:	biology business.industry medicine.medical_treatment Clinical Biochemistry Immunology Autoimmune hepatitis Human leukocyte antigen medicine.disease Proinflammatory cytokine Pathogenesis Cytokine medicine Interleukin 23 biology.protein Immunology and Allergy Interleukin 8 business Interleukin 6
Zdroj:	European cytokine network.
ISSN:	1952-4005
Popis:	Autoimmune hepatitis (AIH) is a chronic hepatitis of unknown etiology and several cytokines have been implicated in its pathogenesis and onset. Our objective was to determine the profile of pro and anti-inflammatory cytokines, including IL-1β, IL-6, IL-8, IL-23, IFN-γ, TNF-α, IL-10 in autoimmune hepatitis and their association with HLA gene polymorphisms. Serum cytokine levels were determined in 50 autoimmune hepatitis patients and one hundred fifty controls using chemiluminescence and ELISA techniques and HLA genotyping performed by PCR SSP. The levels of IL-6 (12 pg/mL vs. 5.5 pg/mL, p = 0.017), IL-8 (24.1 pg/mL vs. 7.8 pg/mL, p = 0.006), and TNF-α (61.1 pg/mL vs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e92d416ff796259161991987ae948b https://pubmed.ncbi.nlm.nih.gov/33270020 Zobrazit plný text záznamu Full text from SpringerLink