Pectin-Derived Acidic Oligosaccharides Improve the Outcome of Pseudomonas aeruginosa Lung Infection in C57BL/6 Mice
| Autor: | Bernd Carsten Stahl, Jean-Luc Desseyn, Marie-Odile Husson, Frédéric Gottrand, Henry Bernard, Nana Bartke |
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| Přispěvatelé: | Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Nutricia Research, The study was funded by grants from the French Association 'Vaincre la Mucoviscidose': grant number 2009/IC0916, 2010/IC1018) for purchasing mice and materials, and Nutricia Research for providing the experimental diets., We thank the staff of the animal facility Dhure/IMPRT/IFR114., Lille Inflammation Research International Center - U 995 [LIRIC], Lille Inflammation Research International Center (LIRIC) - U995 |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
C57BL/6
Lung Diseases Male 030309 nutrition & dietetics MESH: Pseudomonas Infections/immunology Volatile lcsh:Medicine Oligosaccharides MESH: Feces/chemistry medicine.disease_cause Inbred C57BL [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract Mice Feces MESH: Pneumonia/drug therapy MESH: Pectins/chemistry [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases MESH: Animals lcsh:Science MESH: Bacterial Load/immunology MESH: Oligosaccharides/therapeutic use MESH: Treatment Outcome 0303 health sciences Gastrointestinal tract Animals Bacterial Load Diet Fatty Acids Pectins Pneumonia Pseudomonas Infections Pseudomonas aeruginosa Survival Analysis Treatment Outcome Multidisciplinary biology MESH: Lung Diseases/complications 3. Good health medicine.anatomical_structure MESH: Lung Diseases/microbiology MESH: Survival Analysis MESH: Pseudomonas aeruginosa Absolute neutrophil count medicine.symptom MESH: Lung Diseases/immunology MESH: Pneumonia/complications Research Article MESH: Pneumonia/immunology Inflammation MESH: Pseudomonas Infections/drug therapy Microbiology 03 medical and health sciences Immune system MESH: Diet MESH: Mice Inbred C57BL MESH: Fatty Acids Volatile/metabolism medicine MESH: Pseudomonas Infections/microbiology 030304 developmental biology Lung MESH: Lung Diseases/drug therapy lcsh:R Fatty Acids Volatile biology.organism_classification MESH: Male MESH: Pseudomonas Infections/complications Mice Inbred C57BL MESH: Pneumonia/microbiology lcsh:Q [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2015, 10 (11), pp.e0139686. ⟨10.1371/journal.pone.0139686⟩ PLoS ONE, Vol 10, Iss 11, p e0139686 (2015) PLoS ONE, 2015, 10 (11), pp.e0139686. ⟨10.1371/journal.pone.0139686⟩ |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0139686⟩ |
| Popis: | International audience; The administration of prebiotics as oligosaccharides (OS), by acting on intestinal microbiota, could modulate the immune and inflammatory response and represent a new strategy to improve the outcome of bacterial infection. The aim of this study was to determine whether pectin-derived acidic oligosaccharides (pAOS) could modulate the outcome of pulmonary P. aeruginosa (PA) infection in C57BL/6 mice, which develop a Th1 response to PA lung infection. Mice were randomized for 5 weeks to consume a control or a 5% pAOS diet and chronically infected by PA. Resistance to a second PA infection was also analyzed by reinfecting the surviving mice 2 weeks after the first infection. Compared with control mice, mice fed pAOS had reduced mortality (P |
| Databáze: | OpenAIRE |
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