An initial depression of respiration of a cell suspension by L-thyroxine
| Autor: | Hugh J. Phillips |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Molar
medicine.medical_specialty chemistry.chemical_element Kidney Iodine General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Oxygen Consumption Internal medicine Respiration medicine Animals General Pharmacology Toxicology and Pharmaceutics Triiodothyronine Diiodotyrosine Albumin Serum Albumin Bovine General Medicine Iodides Rats Thyroxine medicine.anatomical_structure Endocrinology chemistry Thyronine Protein Binding |
| Zdroj: | Life Sciences. 7:245-250 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(68)90018-0 |
| Popis: | Cell suspensions were prepared from rat kidney by passing minced tissue through a 35 mesh stainless steel screen. The cells were viable and respiration was linear with time. L-thyroxine at a concentration of 10 −5 molar depressed respiration with an hour. The degree of response was directly related to the dose of thyroxine used. Triiodothyronine and D-thyroxine had a similar effect. Potassium iodide, diiodotyrosine or thyronine did not alter respiration. Albumin or serum appeared to block the action of thyroxine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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